NL-OMON21518尚未招募不适用
The Pathophysiology of Disrupted Endothelial Barrier Integrity in septic shock
Amsterdam UMC, location AMC0 个研究点目标入组 30 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 30
研究概览
简要总结
/A
研究设计
- 研究类型
- Observational
入排标准
入选标准
- •=18 years old
- •-Quick SOFA score =2 with suspicion of infection
- •-MAP < 65 mmHg and lactate > 2 mmol/L despite volume resuscitation, requiring vasopressors
- •-Arterial catheter placement as part of standard care
- •-Inclusion within 12 hours after arriving on the IC
排除标准
- •-Absence of informed consent
- •-Major burns = 18%
- •-No arterial catheter placement = 12 hours after arriving on the ICU
- •-Immunosuppressive treatment unrelated to sepsis (recent chemotherapy, chronic use of systemic steroids, methotrexate, tacrolimus, cellcept, ciclosporin, anti-TNF-a antibodies)
- •-HIV infection
- •-Pregnancy or breast feeding
- •-Transfer from another hospital
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