A multicentre, prospective, observational cohort study on the effect of antibiotic use for urinary tract infections on the emergence and spread of antimicrobial resistance in gastrointestinal and oral commensal flora

niversity of Geneva Hospitals (Switzerland)0 个研究点目标入组 1,350 人开始时间: 2010年11月24日最近更新: 2019年2月11日

适应症

试验速览

•1. Adult patients = 18 years old
•2. Presenting with an acute lower or upper, uncomplicated or complicated UTI to the Emergency Room or Outpatient Clinic of the participating GP practices, clinics and hospitals
•3. Requiring an antibiotic treatment of at least one dose
•4. No antibiotics taken within the last 30 days
•5. At least one other person living in the patient's household, defined as a person who spends at least three nights per week in the same house or apartment
•6. Informed consent to the study participation
•Household members (maximum 3) of the index patients will also be invited to participate. Control patients will be recruited from patients (and their household contacts) presenting either with minor trauma or for a gynaecologic exam to the GPs? / outpatient clinics.

•1. Refusal to participate
•2. Unable to give informed consent
•3. Presence of indwelling urinary catheters or urethral pigtail catheters
•4. Renal transplant recipients; acute or chronic renal failure requiring dialysis
•5. Recent discharge from hospital (during the last 30 days)
•6. Treatment with systemic antibiotics within the last 30 days
•7. Patients with severe sepsis or septic shock requiring intensive care
•8. Permanently institutionalized residents of nursing homes or long term care facilities
•9. Follow-up not possible or unlikely to be successful

发起方

niversity of Geneva Hospitals (Switzerland)