A multicentre, prospective, observational cohort study on the effect of antibiotic use for urinary tract infections on the emergence and spread of antimicrobial resistance in gastrointestinal and oral commensal flora

niversity of Geneva Hospitals (Switzerland)0 sites1,350 target enrollmentNovember 24, 2010

Overview

Registry

who.int

Start Date

November 24, 2010

End Date

December 31, 2013

Last Updated

7 years ago

Study Type

Observational

Sex

All

Sponsor

niversity of Geneva Hospitals (Switzerland)

•1\. Adult patients \= 18 years old
•2\. Presenting with an acute lower or upper, uncomplicated or complicated UTI to the Emergency Room or Outpatient Clinic of the participating GP practices, clinics and hospitals
•3\. Requiring an antibiotic treatment of at least one dose
•4\. No antibiotics taken within the last 30 days
•5\. At least one other person living in the patient's household, defined as a person who spends at least three nights per week in the same house or apartment
•6\. Informed consent to the study participation
•Household members (maximum 3\) of the index patients will also be invited to participate. Control patients will be recruited from patients (and their household contacts) presenting either with minor trauma or for a gynaecologic exam to the GPs? / outpatient clinics.

•1\. Refusal to participate
•2\. Unable to give informed consent
•3\. Presence of indwelling urinary catheters or urethral pigtail catheters
•4\. Renal transplant recipients; acute or chronic renal failure requiring dialysis
•5\. Recent discharge from hospital (during the last 30 days)
•6\. Treatment with systemic antibiotics within the last 30 days
•7\. Patients with severe sepsis or septic shock requiring intensive care
•8\. Permanently institutionalized residents of nursing homes or long term care facilities
•9\. Follow\-up not possible or unlikely to be successful