Risk Factors of Paraspinal Muscles in Degenerative Lumbar Spondylolisthesis

Not yet recruiting

• Conditions: Spine Degeneration

• Registration Number: NCT06797700
• Lead Sponsor: The First People's Hospital of Yunnan

Brief Summary

This is a retrospectively observational study. The goal of this observational study is to analyze the risk factors of paraspinal muscles associated with the occurrence of spondylolisthesis in patients with degenerative lumbar spondylolisthesis(DLS) and to construct a predictive model. The main question it aims to answer is: Which paraspinal muscle changes are risk factors for DLS? We will collect the information of patients who have undergone lumbar MRI in our hospital and have been diagnosed with back pain ( including spondylolisthesis or no spondylolisthesis) during the period from 2022 to 2024.The collected data included gender, age, body mass index (BMI), diabetes, hypertension, occupation and imaging parameters. We will then retrospectively analyze the risk factors associated with lumbar spondylolisthesis.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-01
• Study First Submitted: 2025-01-23
• Study First Submitted QC: 2025-01-23
• Study First Posted: 2025-01-28
• Last Update Submitted: 2025-03-04
• Last Update Posted: 2025-03-05
• Study Start: 2025-03-06
• Primary Completion: 2025-04-30
• Study Completion: 2025-08-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• Patients who presented to our hospital with back pain(the diagnosis was spondylolisthesis or no spondylolisthesis);
• Patients older than 50 years;
• Patients with complete clinical data and magnetic resonance imaging (MRI) before surgery.

Exclusion Criteria

• The patient has previous spinal surgery;
• Patients with lumbar tumor,lumbar infection and lumbar tuberculosis;
• Patients with incomplete MRI sequence.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
the MF FCSA	Two weeks before treatment	The functional cross-sectional areas of the multifidus muscl.Measurement it on axial T2-weighted magnetic resonance (MR) images from the L4 vertebral body levels
the ES FCSA	Two weeks before treatment	The functional cross-sectional areas of the erector spinae.Measurement it on axial T2-weighted magnetic resonance (MR) images from the L4 vertebral body levels
the MF CSA	Two weeks before treatment	the total cross-sectional areas of the multifidus muscl.Measurement it on axial T2-weighted magnetic resonance (MR) images from the L4 vertebral body levels
the ES CSA	Two weeks before treatment	the total cross-sectional areas of the erector spinae.Measurement it on axial T2-weighted magnetic resonance (MR) images from the L4 vertebral body levels

Secondary Outcome Measures

Name	Time	Method
SMI	Two weeks before treatment	The skeletal muscle index.SMI = l CSA of muscle on an axial scan (expressed as cm2) divided by the square of the patient's height (expressed as cm2).

Trial Locations

Locations (1)

The First People's Hospital of Yunnan; 🇨🇳 Kunming, Yunnan, China