Pain and hypoxia in premature neonates

Completed

• Conditions: Procedural pain in premature neonates; Signs and Symptoms; Acute pain

• Registration Number: ISRCTN49512764
• Lead Sponsor: ational Institutes of Health, National Institute of Nursing Research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-05-21
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 260

Inclusion Criteria

Premature infants <36 weeks gestation who:
1. Weigh >800 grams
2. Have an arterial or central line catheter in place
3. Require endotracheal suctioning or heel lance

Exclusion Criteria

1. Unstable oxygenation and hemodynamic status due to persistent pulmonary hypertension (PPHN)
2. Cyanotic heart disease
3. Severe respiratory distress
4. Septic shock
5. Taking medications such as morphine, fentanyl, versed, muscle relaxants, phenobarbital, or dilantin
6. Intraventricular hemorrhage grade 3 or more
7. Seizures
8. Facial or multiple congenital anomalies that may alter pain behavior

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Pain score<br>2. Plasma concentration of hypoxanthine, xanthine, uric acid and allantoin

Secondary Outcome Measures

Name	Time	Method
ot applicable.