A Randomized, Double- Blind Multicentric Study of the Effect of Remote Ischemic Preconditioning on Postoperative Complications in Patients Undergoing Major Minimal and Open Visceral Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Postoperative Complication
- Sponsor
- University of Zurich
- Enrollment
- 526
- Locations
- 1
- Primary Endpoint
- Postoperative Complications
- Last Updated
- 11 years ago
Overview
Brief Summary
Remote Ischemic Preconditioning (RIPC) is mediated by intermittent brief episodes (5-10 minutes) of short ischemia in a limb (i.e. arm), followed by reperfusion. For this purpose in 3-4 cycles, a tourniquet is insufflated to suprasystolic pressure levels for 5 minutes and deflated for 5 minutes afterwards. The ischemic episodes are known to stimulate platelets and factors platelet dependent factors such as Serotonin and VEGF. These humoral factors have a systemic effect and have the potential to protect target organs (i.e. heart, kidney, liver) remote to the ischemic limb.
The purpose of this randomized controlled study is to investigate the influence and impact of RIPC on postoperative complications in patients undergoing visceral surgery
Investigators
Eligibility Criteria
Inclusion Criteria
- •\> 18 years
- •Undergoing major visceral surgery
Exclusion Criteria
- •\< 18 years
- •Pregnancy
- •Signs of Infection/Inflammation on upper limb
- •Medical history of axillary lymph node dissection
- •Signs of malperfusion of upper limb (i.e. Allen Test)
- •Missing informed consent
Outcomes
Primary Outcomes
Postoperative Complications
Time Frame: 30 days
Complications will be assessed by Comprehensive Complication Index and Dindo Clavien Score
Secondary Outcomes
- Hospital stay(30 days)
- ICU stay(30 days)
- Infection composite parameters(30 days)