Psychophysiological evaluation of effect of ingestion of oil extracted from krill on brain functio

Not Applicable

• Conditions: Mild cognitive impairment

• Registration Number: JPRN-UMIN000006775
• Lead Sponsor: Department of Neuropsychiatry, Kyorin University School of Medicine

Brief Summary

In the case of memory task, the changes in the oxy-Hb concentrations of the sardine oil and the krill oil groups were significantly greater compared with those of the placebo group at week 12. Regarding ERP, P300 latency of the krill oil group was significantly shorter than that of the placebo group at week 12. About the calculation task, in the krill oil group, the changes in the oxy-Hb concentrations were significantly greater at week 12 than those at week 0. (The 13th Congress of Japan Human Brain Mapping Society)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2010-12-01
• Study Start: 2011-12-20
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: Male
• Target Recruitment: 45

Inclusion Criteria

Not provided

Exclusion Criteria

1) administration of regular medication 2) history of mental disorder or cerebrovascular disease 3) serious liver, kidney, heart, respiratory, endocrine, or metabolic diseases 4) marked abnormal findings for results of blood and urine tests 5) food allergies to fish or crustaceans

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Before starting ingestion, at week 6 and 12, 1) the changes in the oxy-Hb concentration during calculation tasks, and results of performance 2) the changes in oxy-Hb concentration and ERP during memory tasks, and results of performance 3) psychological tests by using POMS, STAI, and the visual analog scale (VAS)

Secondary Outcome Measures

Name	Time	Method
Before starting ingestion, at week 6 and 12, 1) height, weight, and blood pressure 2) results of blood test (white blood cell count, red blood cell count, hemoglobin, and hematocrit) 3) results of blood biochemical test (GOT, GPT, gamma-GTP, creatinine, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, blood sugar, HbA1c, and uric acid) 4) fatty acids in plasma (dihomo-gamma linorenic acid, arachidonic acid, EPA, and DHA) 5) results of urine test (occult blood, urinary protein, urinary sugar, and urobilinogen) 6) nutrient intake by food frequency method