AMYWEB Validation Studies: Assessing Performance on Speech Tasks Via Crowdsourced Participants
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 1,034
- 试验地点
- 1
- 主要终点
- Age, sex, and education adjusted normative scores for the Automatic Story Recall Task (ASRT) test variants derived via linear regression analysis.
研究概览
简要总结
The purpose of the study is to examine the properties of the Automatic Story Recall Test (ASRT) and its parallel variants, as well as letter fluency and category fluency cognitive tests. Tests will be completed in crowdsourced populations, to derive normative data, and examine test properties in demographically diverse and cognitively impaired participants recruited and tested online.
详细描述
The AMYWEB study will validate speech tasks developed by NOVOIC in different population samples, including normative samples, samples recruited for enhanced demographic diversity, and participants with reported cognitive impairment.
Participants will be research volunteers recruited online and via crowdsourcing platforms. Six rounds of recruitment will be completed, evaluating different parallel variants of the Automatic Story Recall Task (ASRT), and fluency tasks. During each recruitment round participants will complete a speech test battery and questionnaires during one assessment (Baseline). Speech tasks will be recorded and later analyzed on Novoic's technology platform. All assessments will be fully online and remote.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •First language must be English
- •Residing in the USA
- •Willing to participate in a study investigating speech and dementia
- •Able to provide informed consent
- •Access to personal computing device that is capable of audio and video recording, and able to connect to the internet
- •Since key research questions are focused primarily on older-age speech and cognition, initial recruitment will be focused on older adult age brackets, which may be extended to younger adulthood if the desired sample sizes are not attained.
排除标准
- •No formal exclusion criteria will apply at the point of recruitment and testing. however, participants with a reported history of neurological conditions or head injury, and current depression will be excluded from normative data development.
结局指标
主要结局
Age, sex, and education adjusted normative scores for the Automatic Story Recall Task (ASRT) test variants derived via linear regression analysis.
时间窗: Baseline
Participants will complete a story recall task (ASRT), which will be administered in triplets (3x stories) with immediate and delayed recall assessed. Six different test phases, recruiting different participant samples, will be completed in which six parallel ASRT triplets will be separately evaluated. Normative data will be generated for each test triplet.
次要结局
- The effect of demographic differences on task performance will be evaluated via linear regression analysis.(Baseline)
- Demographic and cultural biases will be examined via group or pairwise comparison of transcription error rate and scoring errors on a simple reading task.(Baseline)
- Area under the curve (AUC) of the receiver operating characteristic (ROC) curve of the binary classifier distinguishing between the MCI sample and the normative sample using as input the speech elicited during cognitive tasks.(Baseline)
- The agreement between the PHQ-8 and the corresponding regression model predicting depressive symptomatology from speech data elicited during tasks will be evaluated.(Baseline)
- Normative data will be derived for shorter variants of the ASRT test battery derived via linear regression analysis.(Baseline)
- Age, sex, and education adjusted normative scores for the category fluency task performance derived via linear regression analysis.(Baseline)
- Area under the curve (AUC) of the receiver operating characteristic (ROC) curve of the binary classifier distinguishing between depressed and non-depressed participants using as input the speech elicited during cognitive tasks.(Baseline)
- Age, sex, and education adjusted normative scores for the letter fluency task performance derived via linear regression analysis.(Baseline)
- Performance differences in parallel ASRT variant tasks will be examined via task-wise comparison.(Baseline)