Olfaction Disorders in Patients Included in The Trauma Brain Injury (TBI) Database at Trondheim University Hospital: Prevalence and Treatment
Overview
- Phase
- Not Applicable
- Intervention
- corticosteroids
- Conditions
- Brain Injuries
- Sponsor
- St. Olavs Hospital
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- number of patients who have improved olfaction perception (by at least 5 points on the Threshold-Discrimination-Identification (TDI) score
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The aim of the study is to see whether patients with chronic smell impairment after brain injury benefit from a treatment that consists of corticosteroids, and then olfactory training in 3 months.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Registered in the TBI Database
- •18-65 years of age per 01.
- •Olfaction score by Sniffin Sticks Threshold-Discrimination-Identification (TDI) \< 30 confirming dysosmia
Exclusion Criteria
- •Unable to express senses.
- •Unable to follow treatment and protocol
- •pregnancy
- •tendency to infections
- •hypertonia
- •dyspepsia
- •interfering medication (hormonal treatment, NSAIDS, antidiabetics, barbiturates, fenitoin, carbamazepin, rifampicin, cyclophosphamides)
Arms & Interventions
Olfactory disorder after brain trauma
Recruited from 250 patients with moderate to severe traumatic brain injury in the Hodeskadeprosjektet (TBI) cohort. Treatment with (first) corticosteroids and (second) olfactory stimulation.
Intervention: corticosteroids
Olfactory disorder after brain trauma
Recruited from 250 patients with moderate to severe traumatic brain injury in the Hodeskadeprosjektet (TBI) cohort. Treatment with (first) corticosteroids and (second) olfactory stimulation.
Intervention: olfactory stimulation
Outcomes
Primary Outcomes
number of patients who have improved olfaction perception (by at least 5 points on the Threshold-Discrimination-Identification (TDI) score
Time Frame: 1 year
TDI score measured by Sniffin Sticks