Determining the Impact of Dementia and Executive Impairment on Antidepressant Treatment Response in Older Persons
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- depression
研究概览
简要总结
Major depression is a very common health problem affecting older persons. The present standard of treatment is with medications called "antidepressants". Antidepressants have been studied extensively in older persons with normal brain function and have been shown to be effective. However, certain types of brain dysfunction called "executive impairment" (inability to do higher order thinking) may lead to poor treatment outcomes. This study will compare how older depressed people with different levels of executive impairment respond differently to standard antidepressant treatment. Knowing this information will lead to more rational targeting of available treatments, leading to improved treatment outcomes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 90 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •above the age of 65,
- •speak English fluently,
- •experience depression, AND
- •not yet on active treatment.
排除标准
- •active delirium,
- •substance abuse,
- •mental illness other than major depression,
- •active CNS disease,
- •unstable systematic medical disease, OR
- •current of past psychotic disorder.
研究组 & 干预措施
zoloft
Both arms of the study will include zoloft. However, the treatment response to zoloft will be compared in two different subgroups.
干预措施: Zoloft (antidepressant) (Drug)
结局指标
主要结局
depression
时间窗: June 1, 2007 - June 1, 2008
次要结局
未报告次要终点