Cognitive Correlates of Antidepressant Treatment Response in Elders
- Registration Number
- NCT01477268
- Lead Sponsor
- Unity Health Toronto
- Brief Summary
Major depression is a very common health problem affecting older persons. The present standard of treatment is with medications called "antidepressants". Antidepressants have been studied extensively in older persons with normal brain function and have been shown to be effective. However, certain types of brain dysfunction called "executive impairment" (inability to do higher order thinking) may lead to poor treatment outcomes. This study will compare how older depressed people with different levels of executive impairment respond differently to standard antidepressant treatment. Knowing this information will lead to more rational targeting of available treatments, leading to improved treatment outcomes.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
- above the age of 65,
- speak English fluently,
- experience depression, AND
- not yet on active treatment.
- active delirium,
- substance abuse,
- mental illness other than major depression,
- active CNS disease,
- unstable systematic medical disease, OR
- current of past psychotic disorder.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description zoloft Zoloft (antidepressant) Both arms of the study will include zoloft. However, the treatment response to zoloft will be compared in two different subgroups.
- Primary Outcome Measures
Name Time Method depression June 1, 2007 - June 1, 2008
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
St Michael's Hospital
🇨🇦Toronto, Ontario, Canada