Combining MyoCI With Memory Reactivation to Improve Motor Recovery After Stroke

Northwestern University1 site in 1 country70 target enrollmentFebruary 25, 2020

ConditionsStroke

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Stroke
Sponsor: Northwestern University
Enrollment: 70
Locations: 1
Primary Endpoint: Wolf Motor Function Test (WMFT)
Status: Recruiting
Last Updated: 8 months ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This study will examine the combination of myoelectric computer interface (MyoCI) training with targeted memory reactivation (TMR) in chronic stroke survivors. The study aims to determine whether this training-plus-sleep combination will generalize to improve arm motor function over an extended training protocol in stroke survivors.

Registry

clinicaltrials.gov

Start Date

February 25, 2020

End Date

January 30, 2026

Last Updated

8 months ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Northwestern University

Responsible Party

Principal Investigator

Marc Slutzky

Associate Professor

Northwestern University

Eligibility Criteria

Inclusion Criteria

•Age at enrollment is 21 or older
•Hemiparesis from first ever stroke affecting arm movement at least 6 months prior to screening
•Severe to moderate motor impairment (FMA-UE of 7-40)
•At least some voluntary shoulder and elbow muscle activation

Exclusion Criteria

•Inability to follow instructions of the MyoCI task
•Visual impairment (such as hemianopia) preventing full view of screen
•Anesthesia or neglect in the affected arm, or visual hemineglect (score of 2 on the NIH Stroke Scale Extinction and Inattention subtest)
•Participation in another study on the affected arm within 6 weeks of enrollment or any pharmacological study
•Inability to understand or follow commands in English due to aphasia or other reason
•Diffuse or multifocal infarcts in both hemispheres
•Substantial arm pain preventing participation for 90 minutes a day
•Spasticity treatment (pharmacological or Botox) within last 3 months
•Ferromagnetic implants that are MRI incompatible

Outcomes

Primary Outcomes

Wolf Motor Function Test (WMFT)

Time Frame: change from baseline at 6 weeks

The WMFT evaluates upper extremity function on a continuous scale. It measures the time it takes to perform 15 different tasks, with a time limit of 120 s per task.

Secondary Outcomes

Fugl-Meyer Assessment of Upper Extremity (UE) Motor Function(change from baseline at 10 weeks)
Modified Ashworth Scale(change from baseline at 10 weeks)
Motor Activity Log (MAL)(change from baseline at 10 weeks)