临床试验/NCT00611169

NCT00611169已完成4 期

The Effects of Facilitated Percutaeous Coronary Intervention Compared to Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Acute Myocardial Infarction

Samsung Medical Center0 个研究点目标入组 40 人开始时间: 2006年1月最近更新: 2008年2月8日

适应症

干预措施

试验速览

阶段: 4 期
状态: 已完成
发起方: Samsung Medical Center
入组人数: 40
主要终点: Infarct size and its transmural extent using MRI

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者记录与标识符相似试验

研究概览

简要总结

The purpose of this study to investigate whether the administration of high-dose tirofiban before primary PCI could reduce myocardial infarct size, using analysis of contrast-enhanced magnetic resonance imaging.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Parallel
主要目的: Treatment
盲法: None

入排标准

年龄范围: 18 Years 至 80 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•presence of chest pain for more than 30 minutes but less than 12 hours after symptom onset
•ST-segment elevation more than 1 mm in two or more contiguous leads or presumably a new-onset left bundle branch blockage

排除标准

•hemodynamic instability
•history of MI
•old age > 80years
•Patients with bleeding diathesis (coagulopathy, thrombocytopenia or platelet dysfunction, Gastrointestinal or genitourinary bleeding within the prior 3 months)

研究组 & 干预措施

1

Experimental

Aspirin, clopidogrel, unfractionated heparin plus tirofiban infusion at high bolus dose

干预措施: tirofiban (Drug)

结局指标

主要结局

Infarct size and its transmural extent using MRI

时间窗: within the first 30 days after index procedure

次要结局

pre-PCI thrombolysis in myocardial infarction grade, post-PCI myocardial blush grade, ST-segment resolution on electrocardiography, and left ventricular ejection fraction on echocardiography(at 6 month after index procedure)

研究者

发起方

Samsung Medical Center

申办方类型

Other

相似试验

招募中

不适用

Early Tirofiban Administration After Intravenous Thrombolysis in Acute Ischemic StrokeAcute Ischemic Stroke

NCT06045156The First Hospital of Jilin University1,084

已完成

2 期

Tirofiban for Reduction of Thromboembolic Events in Endovascular Unruptured Aneurysm RepairUnruptured Intracranial AneurysmFlow DiverterStent-assisted CoilingThromboembolic Events

NCT06238115Beijing Tiantan Hospital192

已完成

4 期

Intracoronary Tirofiban on No-Reflow PhenomenaNo-Reflow Phenomenon

NCT02054000TC Erciyes University162

已完成

3 期

Advancing Stroke Safety and Efficacy Through Early Tirofiban Administration After Intravenous Thrombolysis (ASSET-IT)Acute Ischemic Stroke

NCT06134622The First Affiliated Hospital of University of Science and Technology of China832

终止

不适用

Antiplatelet Effects of Tirofiban vs. Cangrelor N-STEMI Patients Undergoing Percutaneous Coronary InterventionNon-ST Elevation Myocardial Infarction (NSTEMI)

NCT03048019Inova Health Care Services10