The Effects of Facilitated Percutaeous Coronary Intervention in Acute Myocardial Infarction
- Registration Number
- NCT00611169
- Lead Sponsor
- Samsung Medical Center
- Brief Summary
The purpose of this study to investigate whether the administration of high-dose tirofiban before primary PCI could reduce myocardial infarct size, using analysis of contrast-enhanced magnetic resonance imaging.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- presence of chest pain for more than 30 minutes but less than 12 hours after symptom onset
- ST-segment elevation more than 1 mm in two or more contiguous leads or presumably a new-onset left bundle branch blockage
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Exclusion Criteria
- hemodynamic instability
- history of MI
- old age > 80years
- Patients with bleeding diathesis (coagulopathy, thrombocytopenia or platelet dysfunction, Gastrointestinal or genitourinary bleeding within the prior 3 months)
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 tirofiban Aspirin, clopidogrel, unfractionated heparin plus tirofiban infusion at high bolus dose
- Primary Outcome Measures
Name Time Method Infarct size and its transmural extent using MRI within the first 30 days after index procedure
- Secondary Outcome Measures
Name Time Method pre-PCI thrombolysis in myocardial infarction grade, post-PCI myocardial blush grade, ST-segment resolution on electrocardiography, and left ventricular ejection fraction on echocardiography at 6 month after index procedure