Pilot Study of the Links Between Presbyacusis and Lexical Disorders in Patients With Alzheimer's Disease or Related Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 46
- 试验地点
- 1
- 主要终点
- Link Between Lack of Word and Presbycusis
研究概览
简要总结
In France, Alzheimer's disease accounts for 70 to 80% of the causes of neurocognitive disorders, i.e. 600,000 to 800,000 patients. It is a neurodegenerative pathology that causes evolutionary cognitive dysfunction, mainly affecting memory functions. The inability to name familiar objects (lack of the word) is one of the most commonly noted symptoms at an early stage of the disease.
Presbyacusis, or age-related hearing loss, is the most common sensory deficit in the elderly which is manifested socially by a progressive discomfort of verbal communication. Presbyacusis remains underdiagnosed and undertreated: 2/3 of the patients are not using hearing aid.
In recent years, a link between neurocognitive disorders and hearing loss has been shown by investigating general cognition. In this study, the investigators are investigating lexical disorders.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •> 65 years old
- •French mother tongue
- •Good vision with or without correction
- •Alzheimer's or related disease (15 <Mini-Mental State Examination<25)
- •Affiliate or beneficiary of a social security
- •Informed consent
排除标准
- •Cognitive disorders related to another pathology (cerebrovascular accident, head trauma, epilepsy ...)
- •Protected patient (under guardianship) or person deprived of liberty by judicial or administrative decision
研究组 & 干预措施
LOOP group
Speech therapy consultation for patients with Alzheimer's disease
干预措施: Speech therapy (Other)
结局指标
主要结局
Link Between Lack of Word and Presbycusis
时间窗: at inclusion
The Batterie Informatisée du Manque du Mot (BIMM) is a computerized assessment instrument for denominational disorders. It provides information on level of lexical impairment, type of error (phonological, semantic, visual perceptual) and response time. It comprises two tests: denomination of nouns (42 items, score range from 0 to 42) and of verbs (28 items, score range from 0 to 28). The results are presented in a report including scores, description of qualitative errors, and results per item. A global score of less than 40 indicates a lack of words. The score range is between 0 and 70. The hearing questionnaire consists in 14 questions about concrete situations and a direct question about what the patient thinks of his hearing. Answers are quoted 0, 2 or 4 points. An overall score greater than 14 indicates presbycusis.
次要结局
- Association Between Accommodation Type and Lack of Word(at inclusion)
- Association Between Gender and Lack of Word(at inclusion)
- Association Between Study Level and Lack of Word(at inclusion)
- Association Between Laterality and Lack of Word(at inclusion)
- Association Between Hearing Aid and Lack of Word(at inclusion)
- Association Between Speech Therapy and Lack of Word(at inclusion)
- Association Between Age and Lack of Word(at inclusion)
- Association Between Main Diagnosis and Lack of Word(at inclusion)