Influence of a minimized extracorporeal circulation on angiopoietin-1 and -2, and other markers of endothelial activation, a diagnostic study
- Conditions
- I25.13
- Registration Number
- DRKS00008855
- Lead Sponsor
- niversitätsklinik für Herz- und Thoraxchirurgie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 75
Inclusion Criteria
Coronary of extracorporeal circulation
- Age> 18 years
- Written consent
Exclusion Criteria
- Pre-existing rheumatic or chronic infectious disease (such as systemic lupus erythematosus, ANCA-positive vasculitis, rheumatoid arthritis, etc.)
- Certain medications (cortisol, immunosuppressants, ongoing oncological therapy)
- major surgery in the last 3 months
- renal insufficiency stage 3 or higher (GFR <60ml / min)
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Diagnosis of angiopoietin-1 and -2 as well as other inflammatory and endothelial marker
- Secondary Outcome Measures
Name Time Method - Vital and laboratory values of the first 72h<br>- fluid balance of the first 72 hours<br>- Katecholamindosen the first 72h<br>- organ dysfunction (Sequential Organ Failure Assessment [SOFA] and other scores)<br>- consumption of blood products<br>- hospital stays and intensive care hospital<br>- survival<br>- Quality of Life