Pioglitazone Intervention for Coronary Atherosclerosis in Patients with Acute Coronary Syndrome.
Phase 2
- Conditions
- Acute coronary syndrome
- Registration Number
- JPRN-C000000344
- Lead Sponsor
- Department of Cardiovascular Medicine Saitama Medical University International Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Not provided
Exclusion Criteria
LVEF < 40% Newly onset of congestive heart failure Treatment with insulin Type 1 diabetes Severe liver dysfunction, severe renal dysfunction Already treatment with pioglitazone History of side effects of thiazolidines CD36 defficiency Pregnancy or possible pregnancy A case whose attending physician decides he is not a candidate for the study by any reason.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in volumes of coronary atherosclerotic plaques evaluated by intravascular ultrasound Change in histological components of coronary atherosclerotic plaques evaluated by intravascular ultrasound Change in plasma lipid profile Change in plasma inflammatory markers
- Secondary Outcome Measures
Name Time Method Death, Acute myocardial infarction, Onset of angina whose culprit lesion is subjective coronary plaque, Severe heart failure