Muco-ciliary Cleansing of Lungs in COPD With and Without a Salt Particle Inhaler
- Conditions
- COPDCopd Bronchitis
- Registration Number
- NCT03927365
- Lead Sponsor
- Liita Care ApS
- Brief Summary
Cross-over trial of the effect of a salt particle inhaler on pulmonary muco-ciliary cleansing in COPD patients as measured by lung scintigraphy.
- Detailed Description
Stable COPD patients will be examined twice with minimum two, maximum 14 days interval. In randomized order the patients will inhale from a salt particle inhaler with (active) or without (placebo) content.
Recruitment & Eligibility
- Status
- SUSPENDED
- Sex
- All
- Target Recruitment
- 35
- COPD grade 1, 2 and 3 in stable condition (less than 10% change of FEV1 ratio between investigation visits
- Pregnant or lactating women
- Patients exposed to radionuclear isotopes within one month
- Patients under antibiotic treatment
- Patients with known hyper reactive airways
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Muco-ciliary clearance Activity at time 120 minutes Retention of inhaled radioactive marker in percentage
- Secondary Outcome Measures
Name Time Method Registering number of coughs Activity at any time between time zero and 120 minutes Number of coughs during investigation is noted
Collection of sputum Activity at any time between time zero and 120 minutes Sputum during investigation is collected for analysis of radioactivity content
Symptoms in the subjects health Activity at time 120 Subjective symptom description during investigation is done by a questionnaire
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
Trial Locations
- Locations (1)
Rigshospitalet, Clin nuclear and physiolog dept.
🇩🇰Copenhagen, Denmark
Rigshospitalet, Clin nuclear and physiolog dept.🇩🇰Copenhagen, Denmark