Effect of Perioperative Use of Glycopyrrolate on Lung Function in Patients Under General Anesthesia

Not Applicable

Recruiting

• Conditions: Glycopyrrolate
• Interventions: Other: normal saline; Drug: Glycopyrrolate

• Registration Number: NCT05693246
• Lead Sponsor: Zhuan Zhang

Brief Summary

Gastrointestinal tumor is one of the highest incidence of malignant tumors in our country, with the incidence increasing year by year. Laparoscopic gastrointestinal surgery ,due to having less bleeding ,small trauma ,Rapid recovery ,has become the main means for the treatment of gastrointestinal surgery. Under general anesthesia, mechanical ventilation can lead to repeated mechanical dilation of alveoli, which can lead to mechanical injury of alveolar epithelium, reduce lung compliance, affect lung function, and increase postoperative complications and hospital stay of patients. Glycopyrrolate acts selectively on M1 and M3 receptors, and is 3-5 times more selective to M3 and M1 receptors than M2 receptors. Therefore, as preoperative medication for elderly patients, it has less effect on the cardiovascular system and can stabilize the heart rate,compared with atropine.However, its influence on the respiratory system in the field of anesthesia is only limited to the study of inhibiting glandular secretion at present, and there are no clear reports on the study of respiratory mechanics .The purpose of this study was to investigate the effects of glycopyrrolate on lung function and respiratory mechanics in elderly patients after general anesthesia, in order to guide clinical medication.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-10-01
• Study First Submitted: 2022-12-03
• Study First Submitted QC: 2023-01-12
• Study First Posted: 2023-01-20
• Status Verified: 2024-01
• Last Update Submitted: 2024-01-23
• Last Update Posted: 2024-01-24
• Primary Completion: 2024-03-30
• Study Completion: 2024-03-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

1. Elderly patients undergoing elective laparoscopic radical surgery for gastrointestinal malignant tumors;
2. ASA Grade I-III;
3. BMI 18 to 30 kg /㎡；
4. Operation time≥2 hours.

Read More

Exclusion Criteria

1. Hypersensitivity to glycopyrrolate；
2. Clinical diagnosis of hepatic and renal insufficiency；
3. Complicated myasthenia gravis；
4. Prolonged QT interval and other abnormal electrocardiogram；
5. History of mechanical ventilation within six months before surgery；
6. Combined with glaucoma；
7. The patient refused.

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control	normal saline	-
Glycopyrrolate	Glycopyrrolate	-

Primary Outcome Measures

Name	Time	Method
the changes in lung compliance	10 minutes after intubation; 10 minutes after pneumoperitoneum; 1 hour after pneumoperitoneum; End of pneumoperitoneum for 10 minutes	Lung compliance refers to the degree to which the lungs change under external forces

Secondary Outcome Measures

Name	Time	Method
the changes in oxygenation index	10 minutes after intubation; 10 minutes after pneumoperitoneum; 1 hour after pneumoperitoneum; End of pneumoperitoneum for 10 minutes	Oxygenation index is an important indicator of lung function

Trial Locations

Locations (1)

the Affiliated Hospital of Yangzhou University, Yangzhou University; 🇨🇳 Yangzhou, Jiangsu, China