Study on the central mechanism of acupuncture in treating migraine based on multimodal brain NMR
- Conditions
- chronic migraine
- Registration Number
- ITMCTR2024000210
- Lead Sponsor
- Shanghai General Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
To be eligible for the study, patients with chronic migraine must meet all of the following inclusion criteria:
1. Meet the diagnostic criteria for chronic migraine in the International Classification of Headache Disorders (ICHD-3) of the Headache Classification Committee of the International Headache Society;
2.18-60 years old, education period =6 years, right-handed;
3. The number of headache attacks per month is =15 days, the frequency of migraine attacks per month is =2 times, lasting for more than 3 months, of which at least 8 days have migraine characteristics;
4. Basically normal brain structure, no previous history of depression, cerebrovascular disease, Parkinson's disease or other extrapyramidal diseases, no history of major diseases of other systems;
5. No obvious long-term chronic pain in other parts of the body, such as chronic waist and leg pain, neck pain, etc.;
6. Have not received non-drug treatment such as acupuncture therapy in the past 4 weeks, and have not taken drugs that have the effect of preventing and treating migraine, such as beta blockers, calcium channel blockers, anti-epileptic drugs, antidepressants and 5-HT receptor blockers;
7. No MRI detection contraindications;
8. The subjects signed the informed consent and volunteered to participate in the experiment.
To be eligible for study, healthy subjects must meet all of the following inclusion criteria:
1. Does not meet the diagnostic criteria for migraine;
2. Age 18-45 years old, education period =6 years, right-handed;
3. Basically normal brain structure, no previous history of depression, cerebrovascular disease, Parkinson's disease or other extrapyramidal diseases, no history of major diseases of other systems;
4. No MRI detection contraindications;
5. The subjects signed the informed consent and volunteered to participate in the experiment.
1. Headache caused by organic diseases or other types and parts;
2. SAS score =50 points on anxiety self-rating scale;
3. Severe anatomical asymmetry or clear lesions were found in MRI scan;
4. Abusers of alcohol or other addictive drugs;
5. Unable to cooperate with the researcher.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method