Effect of treatment with atorvastatin on asthma
Phase 3
Recruiting
- Conditions
- Asthma.Mixed Asthma
- Registration Number
- IRCT2017102216367N2
- Lead Sponsor
- Vice chancellor for research, 7th floor, Central building of SUMS, Zand Ave
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
Asthma patients with a history of more than one year, aged 18 till 60 years are enrolled. Exclusion criteria: Lower respiratory infection 4 weeks before entering the study; more than 10 pack-year of smoking or smoking in the last 3 months; pregnancy or breastfeeding; current use of statins or previous side effects of statin or drugs that interact with statins such as antifungal, antibiotic macrolide, cyclosporine, germifibrosil, verapamil and amiodarone; hepatitis or active liver disease; myopathy or myositis.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum level of periostin. Timepoint: Befor intervention and eight weeks after intervention. Method of measurement: ng/mL.;Serum level of IL-13. Timepoint: Befor intervention and eight weeks after intervention. Method of measurement: pg/mL.
- Secondary Outcome Measures
Name Time Method Adverse drug/placebo reaction. Timepoint: 4 and 8 weeks after intervention. Method of measurement: Ask from the patient and laboratory data.;Forced expiratory volume in first second. Timepoint: Before intervention and 4 and 8 weeks later. Method of measurement: liters per minute.