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Vitamin B12 Supplementation Study

Not Applicable
Completed
Conditions
Vitamin B12 Deficiency
Registration Number
NCT00826657
Lead Sponsor
USDA, Western Human Nutrition Research Center
Brief Summary

We hope to learn the clinical and functional signs of sub-clinical vitamin B12 deficiency and its response to supplementation in non-anemic, non-pregnant, and non-lactating women in Rural Mexico. Vitamin B12 is important in hematopoiesis, neuro-cognitive functions and genetic integrity. However vitamin B12 is only found in animal source foods therefore a large segment of the population in developing countries and those practicing vegetarianism are at risk of deficiency of the vitamin. This information will help decide weather supplementation with vitamin B12 is necessary in such populations for public health reasons.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
Female
Target Recruitment
180
Inclusion Criteria
  • Women age 20-59, apparently healthy, no severe B12 deficiency
Exclusion Criteria
  • pregnancy, lactation, anemia and disease states

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
response to B12 supplementation in serum B12, Methylmalonic acid, homocystein, and holotranscobalamin concentrations0 and 3 mos
Secondary Outcome Measures
NameTimeMethod
DNA methylation change, and hematological response to B12 supplementation0 and 3 mos

Trial Locations

Locations (1)

Universidad Autonoma de Queretaro

🇲🇽

Queretaro, Mexico

Universidad Autonoma de Queretaro
🇲🇽Queretaro, Mexico

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