Exploratory research on pharmacological predictors for postoperative bleeding after colon polyp resection in patients taking direct-acting oral anticoagulants
Not Applicable
Recruiting
- Conditions
- colon polyp
- Registration Number
- JPRN-UMIN000032017
- Lead Sponsor
- Tokyo Medical University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 113
Inclusion Criteria
Not provided
Exclusion Criteria
1. Patients who have not consented to participate in this study. 2. Patients taking 3 or more antithrombotic drugs. 3. Patients with serious complications (heart failure, kidney failure, liver failure, respiratory failure). 4. Patients who are pregnant or breastfeeding. 5. Other patients determined to be unsuitable as clinical study subjects by the principal (sub) investigator.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The effect of DOAC trough drug blood concentration (p-Xa activity) on postoperative gastrointestinal bleeding after colon polyp resection in patients taking DOAC
- Secondary Outcome Measures
Name Time Method (1) The effect of DOAC (Tmax) drug blood concentration (PXa activity) on postoperative bleeding after colon polyp resection in patients taking DOAC. (2)The effect of polymorphism of drug-metabolizing enzymes on postoperative bleeding after colon polyp resection. (3) Effect of blood coagulation markers on postoperative bleeding after colon polyp resection. (4) Extraction of endoscopic characteristics of colon polyps for postoperative bleeding after colon polyp resection. (5) Extraction of pathological characteristics of colon polyps for postoperative bleeding after colon polyp resection. (6) Correlation of CHADs score on postoperative bleeding after colon polyp resection.