Active Screening of Latent Tuberculosis Infection in School Contacts of Active Tuberculosis Patients
- Conditions
- TuberculosisLatent Tuberculosis Infection
- Interventions
- Diagnostic Test: QuantiFERON-TB Gold (QFT) test
- Registration Number
- NCT06033807
- Lead Sponsor
- Huashan Hospital
- Brief Summary
The goal of this observational study is to investigate the proportion of Mycobacterium tuberculosis (MTB) infection in school contacts of active tuberculosis (ATB) patients. The main questions it aims to answer are:
* the proportion of MTB infection among school contacts of ATB patients
* risk factors related to tuberculosis (TB) infection
* health economic evaluation of screening strategy
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 31440
- 13 years old or above;
- Students in junior middle school, high school and university;
- Close contact of school active tuberculosis case (e.g. in the same classroom, in the same dormitory);
- Himself/herself (together with his/her guardian for age under 18 years old) willing to participate in trial and sign informed consent.
- Current clinical or sputum culture confirmed active tuberculosis
- Have completed a full course of treatment for ATB or LTBI
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Contacts QuantiFERON-TB Gold (QFT) test School contacts of ATB patients
- Primary Outcome Measures
Name Time Method The prevalence of tuberculosis (TB) infection in school contacts baseline The prevalence of TB infection is defined as the number of participants with positive results in QuantiFERON-TB Gold (QFT) test in study population. Positive result in QFT test indicates higher response than the cut-off value of 0.35 IU / ml of INF-Ξ³ detected in at least one test tube (TB1 or TB2).
- Secondary Outcome Measures
Name Time Method Vaccination history checklist baseline Bacillus Calmette-GuΓ©rin (BCG) vaccination history as possible risk factor of tuberculosis infection.
Co-morbidities / medical history checklist baseline Co-morbidities / medical history \[cardiovascular disease, bronchial asthma, digestive ulcer, nephritic syndrome, glomerulonephritis, diabetes, hyperthyroidism, systemic lupus erythematosus, ankylosing spondylitis, epilepsy, schizophrenia, depression, HIV infection, glucocorticoid use, biologic agent use, immunosuppressive agent use, or other relevant co-morbidities / medical history\]; as possible risk factor of tuberculosis infection.
Age baseline Age as possible risk factor of tuberculosis infection
Sex baseline Sex as possible risk factor of tuberculosis infection.
Patterns of contacting checklist baseline Duration, size of space of exposure to active tuberculosis-infected patient; as possible risk factor of tuberculosis infection.
Trial Locations
- Locations (44)
Qianxi Center of Disease Control
π¨π³Bijie, Guizhou, China
Weining Center of Disease Control
π¨π³Bijie, Guizhou, China
Zhijin Center of Disease Control
π¨π³Bijie, Guizhou, China
Liuzhi Special District Center of Disease Control
π¨π³Liupanshui, Guizhou, China
Panzhou Center of Disease Control
π¨π³Liupanshui, Guizhou, China
Shuicheng District Center of Disease Control
π¨π³Liupanshui, Guizhou, China
Congjiang Ceter of Disease Control
π¨π³Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Danzhai Center of Disease Control
π¨π³Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Huangping Center of Disease Control
π¨π³Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Jianhe Center of Disease Control
π¨π³Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Jinping Center of Disease Control
π¨π³Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Kaili Center of Disease Control
π¨π³Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Leishan Center of Disease Control
π¨π³Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Majiang Center of Disease Control
π¨π³Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Xinpu New Area Center of Disease Control
π¨π³Zunyi, Guiyang, China
Hezhang Center for Disease Control
π¨π³Bijie, Guizhou, China
Jinsha Center for Disease Control
π¨π³Bijie, Guizhou, China
Cengong Center of Disease Control
π¨π³Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Rongjiang Center of Disease Control
π¨π³Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Sansui Center of Disease Control
π¨π³Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Shibing Center of Disease Control
π¨π³Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Taijiang Center of Disease Control
π¨π³Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Tianzhu Center of Disease Control
π¨π³Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Huichuan District Center of Disease Control
π¨π³Zunyi, Guizhou, China
Zhenyuan Center of Disease Control
π¨π³Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
Bozhou District Center of Disease Control
π¨π³Zunyi, Guizhou, China
Chishui Center of Disease Control
π¨π³Zunyi, Guizhou, China
Daozhen Center of Disease Control
π¨π³Zunyi, Guizhou, China
Fenggang Center of Disease Control
π¨π³Zunyi, Guizhou, China
Honghuagang District Center of Disease Control
π¨π³Zunyi, Guizhou, China
Meitan Center of Disease Control
π¨π³Zunyi, Guizhou, China
Renhuai Center of Disease Control
π¨π³Zunyi, Guizhou, China
Suiyang Center of Disease Control
π¨π³Zunyi, Guizhou, China
Tongzi Center of Disease Control
π¨π³Zunyi, Guizhou, China
Wuchuan Center of Disease Control
π¨π³Zunyi, Guizhou, China
Xishui Center of Disease Control
π¨π³Zunyi, Guizhou, China
Yuqing Center of Disease Control
π¨π³Zunyi, Guizhou, China
Zhengan Center of Disease Control
π¨π³Zunyi, Guizhou, China
Dalian Public Health Clinical Center
π¨π³Dalian, Liaoning, China
Dafang Center for Disease Control and Prevention
π¨π³Bijie, Guizhou, China
Qixingguan Center for Disease Control and Prevention
π¨π³Bijie, Guizhou, China
Nayong Center for Disease Control and Prevention
π¨π³Bijie, Guizhou, China
Liping Center for Disease Control and Prevention
π¨π³Linping, Guizhou, China
Qingzhen Center for Disease Control and Prevention
π¨π³Qingzhen, Guizhou, China