A New Method for Estimating Dynamic Positive End-expiratory Pressure. Description and Validation With PEEPi Dyn Measured With Transdiaphragmatic Pressure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Correlation and agreement between AutoPEEP recorded with the transdiaphragmatic pressure (Pdi) vs ecography measurements.
研究概览
简要总结
Dinamic intrinsic PEEP is
详细描述
Dynamic intrinsic positive end-expiratory pressure (PEEPi dyn) play an important pathophysiology role in many acute respiratory pathologies.
The most accurate method to quantify PEEPi dyn is to measure the rise in transdiaphragmatic pressure (Pdi) at end expiration at the point of the contraction of the inspiratory muscles until inspiratory flow starts.
Such method, however, is invasive, poor comfortable and require patient active collaboration.
The purpose of this study is describe a new non-invasive method for estimate PEEPi dyn and validate this method with gold-standard-one.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Acute or chronic respiratory failure
- •Age >=18 y
排除标准
- •Lack of informed consent
- •Controindication to the placement of oesophageal and gastric catheter:
- •esophageal varices, gastric or oesophageal bleeding in the previous 30 days, gastric or oesophageal surgery in the preceding year.
- •Cardiac arrest
- •Severe emodinamic instability (> 1 vasoacttive drug)
- •Acute coronary syndrome (AMI/UA)
- •Inability to protect airway
- •Respiratory arrest
- •Pregnancy suspected or confirmed
- •Diaphragm palsy
- •Curarization in the preceding five hours
- •Mechanical ventilation in controlled mode.
结局指标
主要结局
Correlation and agreement between AutoPEEP recorded with the transdiaphragmatic pressure (Pdi) vs ecography measurements.
时间窗: 20 minutes
次要结局
- Correlation and agreement between neural inspiratory time and ecographic inspiratory time(10 minutes)
- Inter-rater agreement to assest method reliability(10 minutes)
研究者
dr. Stefano Nava
MD
IRCCS Azienda Ospedaliero-Universitaria di Bologna