A New Method for Estimating Dynamic Intrinsic PEEP

Completed

• Conditions: Respiratory Insufficiency; PEEP, Occult; PEEP, Intrinsic

• Registration Number: NCT02388282
• Lead Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna

Brief Summary

Dinamic intrinsic PEEP is

Detailed Description

Dynamic intrinsic positive end-expiratory pressure (PEEPi dyn) play an important pathophysiology role in many acute respiratory pathologies.

The most accurate method to quantify PEEPi dyn is to measure the rise in transdiaphragmatic pressure (Pdi) at end expiration at the point of the contraction of the inspiratory muscles until inspiratory flow starts.

Such method, however, is invasive, poor comfortable and require patient active collaboration.

The purpose of this study is describe a new non-invasive method for estimate PEEPi dyn and validate this method with gold-standard-one.

Study Timeline

• Study First Submitted: 2015-03-09
• Study First Submitted QC: 2015-03-13
• Study First Posted: 2015-03-17
• Study Start: 2015-04
• Status Verified: 2015-08
• Primary Completion: 2015-11
• Study Completion: 2015-11
• Last Update Submitted: 2015-12-28
• Last Update Posted: 2015-12-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Acute or chronic respiratory failure
• Age >=18 y

Exclusion Criteria

• Lack of informed consent
• Controindication to the placement of oesophageal and gastric catheter:

esophageal varices, gastric or oesophageal bleeding in the previous 30 days, gastric or oesophageal surgery in the preceding year.

• Cardiac arrest
• Severe emodinamic instability (> 1 vasoacttive drug)
• Acute coronary syndrome (AMI/UA)
• Inability to protect airway
• Respiratory arrest
• Pregnancy suspected or confirmed
• Diaphragm palsy
• Curarization in the preceding five hours
• Mechanical ventilation in controlled mode.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation and agreement between AutoPEEP recorded with the transdiaphragmatic pressure (Pdi) vs ecography measurements.	20 minutes

Secondary Outcome Measures

Name	Time	Method
Correlation and agreement between neural inspiratory time and ecographic inspiratory time	10 minutes
Inter-rater agreement to assest method reliability	10 minutes

Trial Locations

Locations (1)

Sant'Orsola Malpighi; 🇮🇹 Bologna, Italy