The Effects of Olfactory Stimulation on Diagnosis and Prognosis of Patients With Disorders of Consciousness
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Minimally Conscious State
- Sponsor
- Jing Wang
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Coma Recovery Scale-Revised （CRS-R）
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Analyze the behavioral response of patients with disorders of consciousness through olfactory stimulation, compare the response of olfactory stimulation in patients with different consciousness, and analyze the impact of olfactory stimulation on diagnosis; After the first, third, and sixth months of initial enrollment, the recovery of prognosis was tracked by the Coma Recovery Scale-Revision (CRS-R).
Detailed Description
Previous studies suggested that olfactory stimulus have some effect on some patients with disorders of consciousness. Then, the aim of the present study is to know the prognostic value of olfactory stimulation and the diagnosis for DOC patients. DOC patients were recruited (standard diagnosis procedure is 5 times CRS-R testing within 10 days). The different stimuli were as follows: 1) 1-octene-3-ol, odor. 2) pyridine, odor. 3) water. We presented these stimuli randomly, and we recorded the patient's CRS-R scale behavioral response and response to olfactory stimulation. Analyze the behavioral response of patients with disorders of consciousness through olfactory stimulation, compare the response of olfactory stimulation in patients with different consciousness, and analyze the impact of olfactory stimulation on diagnosis; After the first, third, and sixth months of initial enrollment, the recovery of prognosis was tracked by the Coma Recovery Scale-Revision (CRS-R).
Investigators
Jing Wang
Principal Investigator
Hangzhou Normal University
Eligibility Criteria
Inclusion Criteria
- •18-65 years old;
- •non-acute phase;
- •after coma;
- •no nerve stimulation drugs within 48 hours before the implementation of the study;
- •no neuromuscular blockers within 24 hours before implementation
Exclusion Criteria
- •history of forehead injury;
- •nasal fractures;
- •tracheotomy;
- •developmental mental or neurological diseases leading to recorded dysfunction;
- •severe fractures of the extremities.
Outcomes
Primary Outcomes
Coma Recovery Scale-Revised （CRS-R）
Time Frame: six months later
The CRS-R consists of 23 items grouped in six subscales addressing auditory, visual, motor, oromotor, communication and arousal functions. The higher items represent conscious related behaviour while the lower items for each sub-scale represent reflexive activity. Basis for scoring was the presence or absence of the specific behaviour in response to standard stimuli. Patients were followed up for 1, 3, and 6 months to track the prognosis of patients by CRS-R.