Best Practice Advisory to Initiate High-Intensity Statin Therapy in Patients With Peripheral Artery Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 152
- 试验地点
- 2
- 主要终点
- Frequency of High-Intensity Statin Prescription at 90 days post-discharge
研究概览
简要总结
The purpose of this study is to understand how a Best Practice Advisory (BPA) for high-intensity statin therapy in patients with Peripheral Artery Disease impacts prescription rates.
详细描述
The central hypothesis is that an automated best practice advisory embedded within the electronic medical record (EMR) will improve prescription of high-intensity statins among hospitalized patients with Peripheral Artery Disease (PAD).
Aim 1: To assess the impact of an automated best practice advisory, deployed as part of the standard hospital discharge workflow within the electronic medical record, on high-intensity statin prescription among hospitalized patients with PAD.
Aim 2: To assess the impact of an automated best practice advisory, deployed as part of the standard hospital discharge workflow within the electronic medical record, on short-term cardiovascular outcomes among hospitalized patients with PAD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Primary hospital diagnosis of PAD defined by ICD/CPT codes
- •Inpatient status at the adult hospital at Vanderbilt University Medical Center
- •Not currently prescribed a high-intensity statin (atorvastatin 40-80mg daily or rosuvastatin 20-40mg daily)
排除标准
- •On comfort measures
- •History of statin allergy or intolerance recorded in the EMR
- •History of rhabdomyolysis defined by International Classification of Diseases/Current Procedural Terminology (ICD/CPT) codes
- •History of hepatitis A, B, or C defined by ICD/CPT codes
- •Aspartate aminotransferase >120 units/L within 30 days of alert
- •Alanine aminotransferase >165 units/L within 30 days of alert
- •Primary hospital diagnosis of acute myocardial infarction defined by ICD/CPT codes
- •Primary hospital diagnosis of acute stroke defined by ICD/CPT codes
结局指标
主要结局
Frequency of High-Intensity Statin Prescription at 90 days post-discharge
时间窗: 90 days post-discharge
Frequency will be measured by identifying the number of high-intensity statin prescriptions at 90 days post-discharge.
Frequency of High-Intensity Statin Prescription at discharge
时间窗: Baseline, upon patient discharge through study completion, average of six months
Frequency will be measured by identifying the number of high-intensity statin prescriptions at discharge
次要结局
- Frequency of a Composite of Cardiovascular Events(Baseline, upon patient discharge to 90 days post-discharge through study completion)
研究者
Aaron W. Aday, MD, MSc
Assistant Professor, Division of Cardiovascular Medicine
Vanderbilt University Medical Center