Research on the Efficacy of the "T.O.P. Computer Training" Procedure in the Treatment of Alcohol Dependence

Not Applicable

Completed

• Conditions: Alcohol Dependence

• Registration Number: NCT03338361
• Lead Sponsor: University Ghent

Brief Summary

The investigators evaluate the efficacy of a computerised program (T.O.P. tool) consisting of an approach avoidance training (AAT) (to retrain action tendencies for alcohol-related stimuli), a visual probe training (VPT) (to retrain attentional bias for alcohol-related stimuli) and the combination of both training procedures versus placebo training, as an add-on to treatment as usual (psycho-education and cognitive behavioral therapy).

The investigators include hospitalized detoxified alcohol-dependent patients, who receive a four week training procedure, existing of a pre-assessment, 6 training sessions and a post-assessment.

Outcome measures consist of behavioral measures (consumption of alcohol - self report over 1 year), questionnaires (AUDIT; craving on 9-point likert scale) and approach avoidance and visual probe measurement tasks.

A six month and 1 year follow-up is included (behavioral measures and AUDIT). Further, the investigators will also assess credibility (9-point likert scale) of the training procedure before the start of the training and immediately after the assessment of the AAT and VPT training.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-10-25
• Study Start: 2017-10-26
• Study First Submitted QC: 2017-11-06
• Study First Posted: 2017-11-09
• Primary Completion: 2020-02-29
• Study Completion: 2020-02-29
• Status Verified: 2021-12
• Last Update Submitted: 2021-12-20
• Last Update Posted: 2021-12-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 247

Inclusion Criteria

• hospitalized alcohol-dependent patients, choosing for abstinence en committed to treatment
• detoxification (with benzodiazepines) is terminated
• Dutch speaking

Exclusion Criteria

• neurological condition, such as Korsakoff syndrome
• cognitive problems (cut-off <26/30 on the Montral Cognitive Assessment)
• psychotic disorders
• visual and motor problems at the hands
• non-Dutch speaking
• mental retardation
• patients who are illiterate

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
change in drink behavior	baseline, at 6 months and 1-year post training: change in auditscores between baseline, 6 months and 1-year post-training, and differences between groups	AUDIT score

Secondary Outcome Measures

Name	Time	Method
change in Retraining action tendencies	baseline and between 1 and 7 days after completion of the 6 training sessions: change in action tendencies	The effect on a AAT task
change in Retraining attentional bias	baseline and between 1 and 7 days after completion of the 6 training sessions: change	The effect on a VPT task

Trial Locations

Locations (1)

University Ghent; 🇧🇪 Ghent, Belgium