Efficacy of Approach Avoidance and Attentional Bias Retraining in Alcohol-dependent Patients: a Randomized Controlled Trial in a Clinical Setting
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 247
- 试验地点
- 2
- 主要终点
- change in drink behavior
研究概览
简要总结
The investigators evaluate the efficacy of a computerised program (T.O.P. tool) consisting of an approach avoidance training (AAT) (to retrain action tendencies for alcohol-related stimuli), a visual probe training (VPT) (to retrain attentional bias for alcohol-related stimuli) and the combination of both training procedures versus placebo training, as an add-on to treatment as usual (psycho-education and cognitive behavioral therapy).
The investigators include hospitalized detoxified alcohol-dependent patients, who receive a four week training procedure, existing of a pre-assessment, 6 training sessions and a post-assessment.
Outcome measures consist of behavioral measures (consumption of alcohol - self report over 1 year), questionnaires (AUDIT; craving on 9-point likert scale) and approach avoidance and visual probe measurement tasks.
A six month and 1 year follow-up is included (behavioral measures and AUDIT). Further, the investigators will also assess credibility (9-point likert scale) of the training procedure before the start of the training and immediately after the assessment of the AAT and VPT training.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •hospitalized alcohol-dependent patients, choosing for abstinence en committed to treatment
- •detoxification (with benzodiazepines) is terminated
- •Dutch speaking
排除标准
- •neurological condition, such as Korsakoff syndrome
- •cognitive problems (cut-off <26/30 on the Montral Cognitive Assessment)
- •psychotic disorders
- •visual and motor problems at the hands
- •non-Dutch speaking
- •mental retardation
- •patients who are illiterate
结局指标
主要结局
change in drink behavior
时间窗: baseline, at 6 months and 1-year post training: change in auditscores between baseline, 6 months and 1-year post-training, and differences between groups
AUDIT score
次要结局
- change in Retraining action tendencies(baseline and between 1 and 7 days after completion of the 6 training sessions: change in action tendencies)
- change in Retraining attentional bias(baseline and between 1 and 7 days after completion of the 6 training sessions: change)