KCT0008733
Not yet recruiting
未知
A single-arm phase II trial of Atezolizumab and Bevacizumab with combined radiotherapy in advanced hepatocellular carcinoma with portal vein invasion
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Yonsei University Health System, Severance Hospital
- Enrollment
- 51
- Status
- Not yet recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •(1\) age \=19
- •(2\) clinically or histologically diagnosed HCC
- •(3\) HCC with Vp2\-Vp4 portal vein invasion
- •(4\) intact liver function with Child\-Pugh class A
- •(5\) adequate size of RT field
- •(6\) adequate liver function
- •; AST/ALT \=5 times the upper limits of normal)
- •; no coagulopathy
- •(7\) intact performance with ECOG below 2
- •(8\) non\-pregnant with acceptable contraception in premenopausal women)
Exclusion Criteria
- •(1\) Active uncontrolled infection; (2\) Current or history (\< or \= 5 years) of advanced malignancies in the other organs; (3\) History of liver transplantation; (4\) miliary HCC which incompatible external beam RT
Outcomes
Primary Outcomes
Not specified
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