Comparison Efficacy of platelet-rich fibrin membrane and melatonin on sensory recovery following mandibular fracture

Phase 3

Conditions: ower lip and chin paresthesia due to mandibular fracture.
Disturbances of skin sensation

Registration Number: IRCT20230517058216N1

Lead Sponsor: Yazd University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 45

Inclusion Criteria

Patients whit no history of systemic diseases such as diabetes, kidney and liver problems
Patients with no history of sensitivity to melatonin
Patients who have informed consent to participate in the study
Patients who have no history of previous mandibular surgery and nerve damage
Patients with minimally displaced fractures that require open treatment of the mandible
Patients with a level of GCS of 15, who are fully awake for examinations

Exclusion Criteria

Patients who have dissected nerve fibers at the fracture site
Patients who have soft tissue injuries in the lower lip and chin area.
Patients with mental retardation and psychotic disorders who do not cooperate for examinations
Patients with blood and coagulation disorders

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improving the amount of lower lip paresthesia caused by mandibular fracture. Timepoint: One week, one month and three months. Method of measurement: Two-point discrimination, brush direction detection and self-expression (Visual Analogue Scale) tests.

Secondary Outcome Measures