French COVID Cohort
- Conditions
- Coronavirus Infections
- Registration Number
- NCT04262921
- Lead Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
- Brief Summary
Infectious disease is the single biggest cause of death worldwide. New infectious agents, such as the SARS, MERS and other novel coronavirus, novel influenza viruses, viruses causing viral haemorrhagic fever (e.g. Ebola), and viruses that affect the central nervous system (CNS) such as TBEV \& Nipah require investigation to understand pathogen biology and pathogenesis in the host. Even for known infections, resistance to antimicrobial therapies is widespread, and treatments to control potentially deleterious host responses are lacking.
In order to develop a mechanistic understanding of disease processes, such that risk factors for severe illness can be identified and treatments can be developed, it is necessary to understand pathogen characteristics associated with virulence, the replication dynamics and in-host evolution of the pathogen, the dynamics of the host response, the pharmacology of antimicrobial or host-directed therapies, the transmission dynamics, and factors underlying individual susceptibility.
The work proposed here may require sampling that will not immediately benefit the participants. It may also require analysis of the host genome, which may reveal other information about disease susceptibility or other aspects of health status.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 4415
- Any patient admitted to a health care facility, with an infection confirmed by SARS-CoV-2 (virologically confirmed diagnosis by PCR).
Non inclusion criteria:
- Subject deprived of freedom, subject under a legal protective measure
- Refusal by participant, parent or appropriate representative.
- Confirmed diagnosis of another pathogen than SARS-CoV-2 and no indication or likelihood of co-infection with SARS-CoV-2.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical features 18 months Describe the clinical features of the illness or syndrome (cardio-respiratory signs or symptoms, and laboratory results) and complications, and determinants of severity.
Assessment daily for 15 days, then weekly until max 100 days, then 3 and 6 months.Response to treatment 18 months Describe the response to treatments (including supportive care and novel therapeutics) by clinical, biological, radiological and virological assessments.
Assessment daily for 15 days, then weekly until max 100 days, then 3 and 6 months.Pathogen replication, excretion and evolution, within the host 18 months high-throughput sequencing of pathogen genomes obtained from respiratory tract, blood, urine, stool, CSF and other samples.
Assessment on Day 1, Day 2, Day 3, Day 5, Day 7, Day 9, Day 11, Day 13, Day 15 then weekly until max 100 days, then 3 and 6 months.Immune host responses to infection and therapy 18 months Characterise the innate and acquired immune responses, circulating levels of immune signalling molecules and gene expression profiling in peripheral blood.
Assessment on Day 1, Day 2, Day 3, Day 5, Day 7, Day 9, Day 11, Day 13, Day 15 then weekly until max 100 days, then 3 and 6 months.Host genetic variants Day 1 Identify host genetic variants associated with disease progression or severity
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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Trial Locations
- Locations (97)
CH Cahors
🇫🇷Cahors, France
CHG Agen
🇫🇷Agen, France
CH Annecy Genevois
🇫🇷Épagny, France
Centre Hospitalier Henri Duffaut
🇫🇷Avignon, France
Chu Jean Minjoz
🇫🇷Besançon, France
Centre Hospitalier Pierre Oudot
🇫🇷Bourgoin-Jallieu, France
Chru Hopital Cavale Blanche
🇫🇷Brest, France
CHU Brest
🇫🇷Brest, France
Hospices civils de Lyon
🇫🇷Bron, France
Chms Chambery Nh
🇫🇷Chambéry, France
Hôpital Louis Mourier
🇫🇷Colombes, France
Centre hospitalier Intercommunal de Créteil
🇫🇷Créteil, France
Centre Hospitalier Dax
🇫🇷Dax, France
Centre Hospitalier Du Pays D'aix
🇫🇷Aix-en-Provence, France
CHU Amiens
🇫🇷Amiens, France
CHU Angers
🇫🇷Angers, France
Hôpital Avicenne AP-HP
🇫🇷Bobigny, France
Centre Hospitalier J.E Techer
🇫🇷Calais, France
Centre hospitalier Alpes Leman
🇫🇷Contamine-sur-Arve, France
CHU Ambroise Paré
🇫🇷Boulogne-Billancourt, France
Hopital privé d'Antony
🇫🇷Antony, France
Hôpital de Mercy. CHR METZ-THIONVILLE
🇫🇷Ars-Laquenexy, France
CHU Pellegrin
🇫🇷Bordeaux, France
Ch Fleyriat
🇫🇷Bourg-en-Bresse, France
Centre hospitalier de Béziers
🇫🇷Béziers, France
Centre Hospitalier Andrée Rosemon
🇫🇷Cayenne, France
Centre Hospitalier De Cholet
🇫🇷Cholet, France
CHU Gabriel Montpied
🇫🇷Clermont-Ferrand, France
CH Colmar - Hopital Pasteur
🇫🇷Colmar, France
Hôpital Henri Mondor
🇫🇷Créteil, France
CHU Dijon Bourgogne
🇫🇷Dijon, France
CHU de Martinique
🇫🇷Fort De France, France
Hopital Raymond Poincare
🇫🇷Garches, France
Grand Hopital de l'Est Francilien site Marne-la-Vallée
🇫🇷Jossigny, France
CHU Grenoble
🇫🇷Grenoble, France
CH du Mans
🇫🇷Le Mans, France
Centre Hospitalier Emile Roux
🇫🇷Le Puy-en-Velay, France
Centre Hospitalier Universitaire de Lille
🇫🇷Lille, France
CHRU Lille, Hôpital Salengro
🇫🇷Lille, France
Chd Les Oudairies
🇫🇷La Roche-sur-Yon, France
Hôpital Universitaire Bicêtre
🇫🇷Le Kremlin-Bicêtre, France
Hôpital Louis Raffalli
🇫🇷Manosque, France
CHU de Lille
🇫🇷Lille, France
Assistance publique hopitaux de Marseille, hopital Nord
🇫🇷Marseille, France
Hopital Européen
🇫🇷Marseille, France
Hôpital de la Croix-Rousse
🇫🇷Lyon, France
Groupe Hospitalier Sud Ile De France
🇫🇷Melun, France
CH de Mont Marsan
🇫🇷Mont de Marsan, France
Groupe hospitalier du Havre
🇫🇷Montivilliers, France
Hôpital Conception
🇫🇷Marseille, France
CHU Montpellier
🇫🇷Montpellier, France
CHU Nantes
🇫🇷Nantes, France
Hopital Américain de Paris
🇫🇷Neuilly-sur-Seine, France
CHU de Nice
🇫🇷Nice, France
CHU Caremeau
🇫🇷Nîmes, France
APHP Bichat
🇫🇷Paris, France
APHP Tenon
🇫🇷Paris, France
CH Lariboisière
🇫🇷Paris, France
Groupe Hospitalier Diaconesses Croix Saint-Simon
🇫🇷Paris, France
Hopital Cochin-CIC1417
🇫🇷Paris, France
Hopital Européen Georges Pompidou
🇫🇷Paris, France
Hopital Saint Louis
🇫🇷Paris, France
La pitié salpetrière
🇫🇷Paris, France
Hopital Saint Antoine
🇫🇷Paris, France
Centre Hospitalier de Pau
🇫🇷Pau, France
CH de Perpignan
🇫🇷Perpignan, France
CHU de Poitiers
🇫🇷Poitiers, France
Hopital Lyon Sud-HCL
🇫🇷Pierre-Bénite, France
Centre Hospitalier de Périgueux
🇫🇷Périgueux, France
CHU de Pointe à Pitre
🇫🇷Pointe À Pitre, France
Ch Cornouaille
🇫🇷Quimper, France
Chu Reims
🇫🇷Reims, France
Groupe Hospitalier Sud Réunion
🇫🇷Saint-Pierre, France
CHU de Saint-Etienne
🇫🇷Saint-Étienne, France
CHU Rennes Hopital Sud
🇫🇷Rennes, France
Centre hospitalier Louis Constant Fleming
🇫🇷Saint-Martin, France
Hôpital Pontchaillou
🇫🇷Rennes, France
CHU Charles Nicole
🇫🇷Rouen, France
CH de Saintonge
🇫🇷Saintes, France
N.H.C. - Nouvel Hopital Civil
🇫🇷Strasbourg, France
CHU Rouen Normandie
🇫🇷Rouen, France
CHU Réunion-Felix Guyon
🇫🇷Saint denis, France
Hopital d'instruction des armées Begin 69
🇫🇷Saint-Mandé, France
Centre Hospitalier de Soissons
🇫🇷Soissons, France
Hopital Foch
🇫🇷Suresnes, France
CHR Metz-Thionville -Hopital Bel Air
🇫🇷Thionville, France
Hopitaux du Leman
🇫🇷Thonon-les-Bains, France
Centre Hospitalier Universitaire de Rangueil
🇫🇷Toulouse, France
CHU de Toulouse
🇫🇷Toulouse, France
CHU Toulouse IUCT Institut Universitaire de Cancer de Toulouse
🇫🇷Toulouse, France
CHU Toulouse Larrey
🇫🇷Toulouse, France
Hôpital Gustave Dron
🇫🇷Tourcoing, France
Centre Hospitalier Régional Universitaire de Tours
🇫🇷Tours, France
CHRU de Tours
🇫🇷Tours, France
CHU Nancy
🇫🇷Vandœuvre-lès-Nancy, France
Centre Hospitalier Bretagne Atlantique
🇫🇷Vannes, France
Centre Hospitalier Intercommunal
🇫🇷Villeneuve Saint Georges, France