Epigenome-wide association study identifies a novel DNA methylation in patients with severe aortic valve stenosis
Not Applicable
- Conditions
- patient of aortic valve stenosis and health people
- Registration Number
- JPRN-UMIN000038129
- Lead Sponsor
- Iwate Medical University
- Brief Summary
EWAS revealed that DNA methylation of a CpG site differed significantly between the AS group and controls. The DNA methyltion level of chromosome 8 position 126448033, which is located at TRIB1 (tribbles homolog 1), was lower in the AS group than in the controls
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 188
Inclusion Criteria
Not provided
Exclusion Criteria
clinical signs of acute coronary syndrome, acute infection, severe renal failure (serum creatine levels over 3 mg/dL) or rheumatoid disease, or if they were suspected of having a malignant or primary wasting disorder
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method