ACTRN12613000213741Completed未知
A randomised controlled trial on the efficacy of the selective serotonin re-uptake inhibitor Fluoxetine combined with a computerised multi-sensory training (visual, auditory, tactile) in the treatment of chronic tinnitus in adult sufferers.
The University of Auckland Research Faculty0 sites20 target enrollmentStarted: February 22, 2013Last updated:
Trial Snapshot
- Phase
- 未知
- Status
- Completed
- Sponsor
- Enrollment
- 20
Study Overview
Brief Summary
Multisensory perceptual training resulted in neural connectivity changes consistent with the underlying task. Improvements in tinnitus measures were correlated with changes in sensory and attention networks.
Study Design
- Study Type
- Interventional
- Allocation
- Randomised controlled trial
- Primary Purpose
- Treatment
- Masking
- Blinded (masking used)
Eligibility Criteria
- Ages
- 18 Years to 75 Years (—)
- Sex
- All
Inclusion Criteria
- •Chronic (> 6 months in duration) tinnitus, that is unilateral (lateralised to one side of the head more than the other), occurring in the adult population (age 18 or older). Less than a 70 dBHL hearing loss in the worse-affected ear for any 1 test frequency. Normal tactile sensitivity as per the Von Frey Monofilament screen. Able to see a computer monitor reliably via a vision check. No musculoskeletal contributors to tinnitus that are outside of scope of a spinal-manual therapist's (a registered chiropractor) treatment practise. No precluding factors to administration of SSRI (Fluoxetine) or resting-state MRI, as indicated by questionnaire and review by specialists in the field of pharmacology and MRI.
Exclusion Criteria
- •1) Hearing loss in the worse-affected ear for any 1 test frequency that is 70 dBHL or greater.
- •2) Inability to reliably see a computer monitor as per a field-check of vision.
- •3) Atypical or abnormal tactile sensitivity as indicated by the Von Frey Monofiliment screen.
- •4) Musculoskeletal contributors to tinnitus that are outside of scope of a spinal-manual therapist's (a registered chiropractor) treatment practise.
- •5) Precluding factors to administration of low-dose SSRI (Fluoxetine) as indicated by questionnaire and review by specialists in the field of pharmacology.
- •6) Precluding factors to administration of resting-state MRI as indicated by questionnaire and review by specialists in the field of MRI.
Investigators
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