Resuscitation Strategies in Septic Shock (ReSSeS). A randomized controlled trial of two different fluid loading strategies in ICU patients with early septic shock. - The ReSSeS Study

Medisch Spectrum Twente0 个研究点目标入组 170 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•1 Age > 18 years
•2 Clinical evidence of sepsis (microbiology confirmation, radiological or direct view (pus in biological fluid) or direct surgical view).
•3 * 2 SIRS criteria:
•a. Temperature < 36.0°C or > 38.0°C
•b. Heart rate > 90 bpm
•c. Respiratory rate > 20 rpm or PaCO2 < 4.2 kPa or need of mechanical ventilation.
•d. Leukocytes > 12.0 x109/L or < 4.0 x109/L or >10% bands
•4 Circulatory shock defined as sustained systemic hypotension (systolic arterial pressure <90 mmHg or MAP <65 mmHg (<75 mmHg in a hypertensive patient) despite a 1,000 ml IV fluid challenge over 30 min (including IV fluids administered pre-ICU) or the need for vasopressor therapy. Hypertensive patients are patients with a history of confirmed hypertension treated with antihypertensive agents.
•5 Mechanical ventilation by endotracheal tube (any form)

•1 Pregnancy
•2 Pre-terminal illness with life expectancy <28 days
•3 Duration of circulatory shock >6 hours
•4 Severe peripheral arterial vascular occlusion disease (Fontaine level III-IV)
•5 Inability for femoral artery canulation
•6 No informed consent

发起方