Midodrine is Effective in Management of Intradialytic Hypotension Among Critically-ill Patients With Acute Kidney Injury
- Registration Number
- NCT03431194
- Lead Sponsor
- Benha University
- Brief Summary
The aim of this randomized trial was to assess the efficacy of oral midodrine tablets for the management of intradialytic hypotension among critically ill patients with acute kidney injury.
- Detailed Description
In This open -label study, patients in ICU with acute kidney injury are randomized to either midodrine tablets or placebo. the number of intradialytic episodes and both systolic and diastolic blood pressure between both groups are compared. Mortality and adverse effects are monitored and compared as well.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
- ICU patients
- acute kidney injury
- age above 18 years
- documented hypotension during dialysis
Exclusion Criteria
- packed red blood cells transfusion
- intravenous inotropes
- alteration of blood pressure medications
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description placebo group Placebo Patients receive sugary oral tablets therapy midodrine group midodrine Patients will receive midodrine tablets
- Primary Outcome Measures
Name Time Method Number of hypotensive episodes 30 days from start of hemodialysis Number of hypotensive episodes
- Secondary Outcome Measures
Name Time Method mean systolic blood pressure 30 days from start of hemodialysis compare mean systolic blood pressure between the two arms
mean diastolic blood pressure 30 days from start of hemodialysis compare mean diastolic blood pressure between the two arms
Mortality in each arm 30 days from start of hemodialysis Number of dead patients in each arm