Midodrine is Effective in Management of Intradialytic Hypotension Among Critically-ill Patients With Acute Kidney Injury
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 主要终点
- Number of hypotensive episodes
研究概览
简要总结
The aim of this randomized trial was to assess the efficacy of oral midodrine tablets for the management of intradialytic hypotension among critically ill patients with acute kidney injury.
详细描述
In This open -label study, patients in ICU with acute kidney injury are randomized to either midodrine tablets or placebo. the number of intradialytic episodes and both systolic and diastolic blood pressure between both groups are compared. Mortality and adverse effects are monitored and compared as well.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ICU patients
- •acute kidney injury
- •age above 18 years
- •documented hypotension during dialysis
排除标准
- •packed red blood cells transfusion
- •intravenous inotropes
- •alteration of blood pressure medications
研究组 & 干预措施
midodrine group
Patients will receive midodrine tablets
干预措施: midodrine (Drug)
placebo group
Patients receive sugary oral tablets therapy
干预措施: Placebo (Drug)
结局指标
主要结局
Number of hypotensive episodes
时间窗: 30 days from start of hemodialysis
Number of hypotensive episodes
次要结局
- mean systolic blood pressure(30 days from start of hemodialysis)
- mean diastolic blood pressure(30 days from start of hemodialysis)
- Mortality in each arm(30 days from start of hemodialysis)
研究者
Mahmoud Hamada imam
Lecturer of Internal Medicine
Benha University