Is Plasma High Sensitive Cardiac Troponin I an Indicator of Cardiac Ischemic Injury after exercise test in healthy volunteers?
Recruiting
- Conditions
- Myocardial infarction10019280
- Registration Number
- NL-OMON34396
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
• Age : 18-45 years
• Willing to sign informed consent
• Healthy
Exclusion Criteria
• Hypertension
• Any cardiovascular abnormality in past medical history, physical examination or ECG.
• Drug abuse
• Alcohol abuse (> 3 units/day)
• Smoking
• BMI>=30 kg/m2
• Inability to perform bicycle exercise
• One or more of the items of the questionnaire (American Heart Association 12-point screening for exercise test) scores positive (see appendix of protocol)
• Any signs and symptoms of current infection based on physical examination and medical history
• Medical history of chronic infection or autoimmune diseases
• History of vaccine injection in recent 1 month.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>high sensitive troponin I </p><br>
- Secondary Outcome Measures
Name Time Method <p>Ex-vivo stimulation of leucocytes from blood collected before and after the<br /><br>RIPC-stimulus with measurement of cytokines (TNFa, IL6, IL10) in supernatant.</p><br>