Comprehensive Profiling of Promising Biomarkers in Exosomes From Non-small Cell Lung Cancer With Central Nervous System Metastasis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Lung Cancer With Central Nervous System Metastasis
- Sponsor
- National Taiwan University Hospital
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- predict lung cancer metastasis and Bioindicators of treatment effect
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Cerebrospinal fluid was obtained from the cerebrospinal cavity of non-small cell lung cancer patients with central nervous system metastasis, blood was obtained from veins, and metastatic lung cancer tumor tissue was obtained from surgically resected brain tumors or meningeal tumors. Then comprehensively analyze the exosomes contained in the aforementioned samples, and compare and analyze the clinical data of the patients, so as to explore whether the cancer cell-related substances contained in the cerebrospinal fluid, blood and tumor tissue can be used to predict lung cancer metastasis and Bioindicators of treatment effect.
Investigators
Eligibility Criteria
Inclusion Criteria
- •A. Non-small cell lung cancer patients diagnosed with brain metastases or meningeal metastases on brain computed tomography (CT) or magnetic resonance (MRI) images.
- •B. Patients with non-small cell lung cancer who are about to undergo surgical brain surgery, such as brain tumor resection, lumbar abdominal drainage, Euclidean storage, or ventriculoperitoneal drainage.
Exclusion Criteria
- •A. Non-small cell lung cancer patients without brain metastases or meningeal metastases.
- •B. Physical condition does not allow surgical removal of the tumor.
Outcomes
Primary Outcomes
predict lung cancer metastasis and Bioindicators of treatment effect
Time Frame: follow 3 years
Cerebrospinal fluid was obtained from the cerebrospinal cavity of non-small cell lung cancer patients with central nervous system metastasis, blood was obtained from veins, and metastatic lung cancer tumor tissue was obtained from surgically resected brain tumors or meningeal tumors. Then comprehensively analyze the exosomes contained in the aforementioned samples, and compare and analyze the clinical data of the patients, so as to explore whether the cancer cell-related substances contained in the cerebrospinal fluid, blood and tumor tissue can be used to predict lung cancer metastasis and Bioindicators of treatment effect.