Role of Intravenous Dexamethasone in Prolonging the Duration of Sub-Arachnoid Block in Pregnant Patients Undergoing Lower Segment Cesarean Section
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 发起方
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- Time for block to regress by two dermatomes in post operative period
研究概览
简要总结
Lower segment C section is one of the most commonly performed surgeries worldwide. It is performed in spinal anesthesia. During Spinal Anesthesia a local anesthetic drug is administered in a space surrounding spinal cord and it blocks nerves originating from spinal cord providing both anesthesia and analgesia. This technique avoids harmful exposure of drugs to the baby inside the womb of mother. However this technique provides anesthesia and analgesia of limited duration which can be prolonged by addition of drugs to patient management regimen. One such drug is Dexamethasone which is a steroid commonly administered in the peri-operative period.
详细描述
To prolong the duration of Sub-Arachnoid block number of drugs which are known as adjuvants can be used. One of the commonly used adjuvant is Dexamethasone a steroid given by intravenous route having anti-emetic and anti-inflammatory effect. This drug also prolongs the duration of Sub-Arachnoid block which can be helpful in case of lengthy surgical procedure and also extends the duration of analgesia in the post operative period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 16 Years 至 40 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •American Society of Anesthesiologists (ASA) class: II and above.
- •Elective Cesarean section under Spinal Anesthesia.
排除标准
- •Gestational diabetes
- •Body mass index >35 kg/m2
- •Diabetes mellitus
- •Adrenal insufficiency
- •Chronically receiving steroids
- •Allergic to study medications
- •Sensory block level less than T4
研究组 & 干预措施
Group Dexamethasone
干预措施: Dexamethasone (Drug)
Group Control
干预措施: Placebo (Drug)
结局指标
主要结局
Time for block to regress by two dermatomes in post operative period
时间窗: This will be the time in minutes from end of C section in post operative period for the block to regress by two dermatomes
次要结局
- Time to rescue analgesia(This will be the time in minutes from the end of Cesarean section in the post operative period to first rescue analgesia.)
研究者
Huda Tariq
Principal Investigator
Rawalpindi Medical College