Treatment of marital infertility related to sperm quality problems
Phase 2
Recruiting
- Conditions
- oligospermia
- Registration Number
- RBR-8ccgysm
- Lead Sponsor
- Centro de Referência da Saúde da Mulher
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Couples over the age of 18 years old; duration of infertility over 1 year; women aged 39 years old or younger, undergoing IVF vitro-ICSI; idiopathic oligozoospermia (<15 million / mL), according to guidelines WHO, semen analysis in whole patients was performed 2 or moretimes (sanità, 2010); with no obvious abnormalities observed in medical history, physical examination and endocrine profile; no evidence of genital infections on clinical examination and / or
leukospermia on sperm test.
Exclusion Criteria
obstructive azoospermia; known cytogenetic abnormalities' Y chromosome microdeletions; testosterone level less than 300 ng / dl; women with Bologna criteria for poor respond”
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome will be the rate of live births. This outcome will be compared between groups by Fisher's exact test. The level of significance will be 5%.<br>
- Secondary Outcome Measures
Name Time Method For qualitative variables, as fertilization rates will be compared between groups using Fisher's exact test. The level of significance will be 5%.;For qualitative variables, as the rates of clinical pregnancy will be compared between groups by Fisher's exact test. The level of significance will be 5%.;For qualitative variables, as abortion rates will be compared between groups using Fisher's exact test. The level of significance will be 5%.;For qualitative variables, such as the success rates of TESE will be compared between groups by Fisher's exact test. The level of significance will be 5%.