SLCTR/2021/006尚未招募未知
Efficacy and safety of virgin coconut oil and king coconut oil compared to liquid paraffin as a moisturizer for mild atopic dermatitis: A randomized double-blind study
niversity of Peradeniya0 个研究点开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 尚未招募
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Both male and female
- •Age more than 2 years
- •* Patients diagnosed with atopic dermatitis(AD) defined according to the Hanifin and Rajka criteria f
- •for the diagnosis of AD [Major Criteria: Pruritus, Dermatitis affecting flexural surfaces and the face
- •and extensors in infants, Chronic or relapsing dermatitis, Personal or family history of cutaneous or
- •respiratory atopy
- •Minor criteria: Features of facial pallor or erythema, hypopigmented patches, infraorbital darkening,
- •infraorbital folds or wrinkles, cheilitis, recurrent conjunctivitis and anterior neck folds. Triggers of
- •atopic dermatitis; foods, emotional factors, environmental factors, and skin irritants such as wool,
- •solvents and sweat. Complications of atopic dermatitis: susceptibility to cutaneous viral and
- •bacterial infections, impaired cell mediated immunity, immediate skin-test reactivity, raised serum
- •IgE. Others: early age of onset, dry skin, ichthyosis, hyperlinear palms, keratosis pilaris, hand and
- •foot dermatitis, nipple eczema, white dermatographism and perfollicular accentuation]
- •Diagnosis will be made when there are 3 out of 4 major criteria and 3 out of minor criteria
- •An Investigator’s Global Assessment (IGA) score of 2, corresponding to mild disease. IGA will be
- •performed by the principal investigator (Consultant Dermatologist).
排除标准
- •Presence of AD only on the face
- •Patients who are mentally or physically handicapped
- •Pregnant or lactating women
- •Patients who had used topical or oral steroids during the past two weeks
- •Patients who had used topical calcineurin inhibitors during the past two weeks
- •Patients who had used systemic therapies (Methotrexate, cyclosporine, azathioprine,
- •mycophenolate mofetil [MMF]) during past two weeks
- •Patients with currently infected lesions that require antibiotics
- •Patients with dermatological conditions in addition to AD
- •Patients with hypersensitivity to VCO, king coconut oil or liquid paraffin
- •Patients with any concomitant medication that could aggravate AD
- •Medications: retinoids, topical corticosteroids (prolonged use), diuretics, lipid?lowering agents,
- •calcium antagonists, beta-blockers, and rheumatic drugs, contraceptives/antiandrogens, cytostatic
- •Patients with any comorbidity that could aggravate AD
- •Comorbidities: heart failure/ chronic kidney disease/ diabetes mellitus/ hepatopathies (e.g., primary
- •biliary cholangitis, primary sclerotic cholangitis, drug?induced cholestasis, extrahepatic
- •cholestasis)/
- •hyperparathyroidism/ hypo or hyperthyroidism/ iron deficiency
- •Patients with any of the following medical conditions
- •Medical conditions: chronic inflammatory bowel disease/ rheumatic diseases/ infections such as
- •diarrheal diseases, helminths, hepatitis B and C virus and HIV/ hematological and
- •lymphoproliferative diseases/ malnutrition due to hypovitaminosis (vitamin D, vitamin A, niacin
- •deficiency), zinc or iron deficiency
- •* Patients using topical steroids and other emollients
研究者
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