Cardiac changes in pre-eclamptic women in pregnancy

Not yet recruiting

Conditions: Pregnancy, childbirth and the puerperium,

Registration Number: CTRI/2021/05/033524

Lead Sponsor: Kasturba medical college

Brief Summary: Preeclampsia is a multisystem disorder that can affect almost every organ. Cardiopulmonary morbidity is seen in significant proportion of preeclampsia cases. This study is mainly to test the ventricular function, strain and strain rate of the left and right ventricle, using speckle tracking echocardiography. Written and informed consent will be taken from the patient. Maternal characteristics like height, weight, BMI will be noted. General physical examination, baseline laboratory investigations and routine preeclampsia investigations will be sent. Patients will be categorized into mild and severe preeclampsia. Recruited patients will be examined in left lateral decubitus position using commercial ultrasound scanner from 24-36 weeks. Transthoracic echocardiography with Speckle tracking echocardiography using GE VIVID S60 2D echocardiographic system 1.3-4.5 Mhz 3Sc-RS adult probe. Standard views: parasternal long axis, short axis, 2,3,4 chamber view. LA,LV diameter and wall thickness to be measured using M mode echocardiography. Multidirectional analysis of LV global longitudinal strain (GLS) will be performed using 2D speckle tracking echocardiography by the apical 2,3,4 chamber views. LV is divided into 6 segments in each apical view. All the images will be recorded with frame rate of 50 frames per second. Left ventricular GLS will be derived from average of 6 segmental peak systolic strain values and Right ventricular global longitudinal strain from 3. Echocardiography will also be done 6 weeks post partum to assess if the cardiovascular changes are persistent or have any residual deficit or if they are returning to normal

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: Female

Target Recruitment: 16

Inclusion Criteria

Singleton pregnancy atleast 28 weeks to 36 weeks of gestation, with diagnosis of preeclampsia according to ACOG.

Exclusion Criteria

Multifetal gestation Pre-exisiting cardiac disease.
Diabetes mellitus type 1 or 2.
Pre-existing pulmonary disease.
Gout, connective tissue, renal and hepatic disease.
Cervical incompetence.
Any fetal anomaly detected.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Left ventricular strain	At 28-32 weeks of pregnancy \| 6 weeks post partum
Left ventricular strain rate	At 28-32 weeks of pregnancy \| 6 weeks post partum

Secondary Outcome Measures

Name	Time	Method
left ventricular strain	functions of ventricles

Trial Locations

Locations (1): Kasturba medical college
🇮🇳
Udupi, KARNATAKA, India
Kasturba medical college
🇮🇳Udupi, KARNATAKA, India
Dr Ruthvika
Principal investigator
9700810820
ruthvikakundoor88@gmail.com