New Diagnosis Of Vestibular Vertigo With Functional MRI
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 4
- 主要终点
- Activation of target sites on the functional MRI images during the vestibular response
研究概览
简要总结
The purpose of this study is to determine the potential usefulness of new functional MRI in diagnostic assessment of patients presenting with vertigo.
详细描述
The incidence of vertigo has been reported to be as high as 1.5% in the general population and some reports suggest that more than 5% of adults experience some kind of vertigo each year. In 80% of affected individuals, this symptom resulted in a medical consultation, interruption of daily activities, or sick leave. Therefore, vertigo can have a significant impact on health and well being. Unfortunately, there is not yet any satisfactory objective method for diagnosis of vertigo. At present, the diagnosis usually depends on medical history, vestibular function tests, Dix-Hallpike positioning tests done in the office, and, to some extent imaging studies doen to look for such abnormalities such as acoustic tumor, brain tumor, and evidence of multiple sclerosis. A number of recent studies support the possibility of using functional MRI (fMRI), particularly a new diffusion tensor fiber tracking (DTT) technique, as a new tool for diagnosis of disorders that can cause vertigo. In this study, our hypothesis is that there is an alteration in the activity in neural pathways of patients with vertigo that can be detected by fMRI. To test this assumption, our objective in this study is to determine whether there is a difference between the fMRI images obtained in normal subjects versus those in patients with vertigo.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteer or patient with symptom of vertigo
排除标准
- •Evidence of mental impairment
- •Any type of bioimplant or any type of ferromagnetic bioimplant
- •Pregnant females
- •Exhibit noticeable anxiety and/or claustrophobia
- •History of serious disease in central nervous and cerebrovascular systems.
结局指标
主要结局
Activation of target sites on the functional MRI images during the vestibular response
时间窗: Not specific
次要结局
- Differences in the fiber tracking of central nervous system specifically involved in the vestibular response(Not specific)
