The Comparison of Desflurane and Sevoflurane on Postoperative Recovery and Hepatic Function of Biliary Atresia Patients During Kasai Operation

Not Applicable

Completed

• Conditions: Kasai Operation; Biliary Atresia
• Interventions: Drug: sevoflurane anesthetics; Drug: desflurane anesthetics

• Registration Number: NCT01443572
• Lead Sponsor: Yonsei University

Brief Summary

Biliary atresia (BA) is a perinatal disease of unclear etiology, characterized by inflammation and obliteration of intrahepatic and extrahepatic bile ducts, leading to cholestasis and cirrhosis. Kasai operation remains as the first line operative treatment in BA. In the previous studies, inhalation anesthetics might induce liver damage. The choice of inhalation anesthetic that minimally affects hepatic function is important. Therefore, the purpose of this study is to compare the postoperative recovery and hepatic function between desflurane and sevoflurane, two most frequently used inhalational anesthetics in patients undergoing Kasai operation.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-09
• Study First Submitted: 2011-09-16
• Study First Submitted QC: 2011-09-28
• Study First Posted: 2011-09-29
• Status Verified: 2014-07
• Primary Completion: 2014-07
• Study Completion: 2014-07
• Last Update Submitted: 2014-07-20
• Last Update Posted: 2014-07-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• patients with biliary atresia undergoing Kasai operation

Exclusion Criteria

• patients with congenital anomalies at major organs

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
sevoflurane group	sevoflurane anesthetics	-
desflurane group	desflurane anesthetics	-

Primary Outcome Measures

Name	Time	Method
Change in hepatic function	after operation, and on the 1st, 2nd, 3rd, 5th, 7th and 15th postoperative days	Complete blood count(CBC), prothrombin time(PT), activated partial thromboplastin time(APTT), aspartate aminotransferase(AST), alanine aminotransferase(ALT), alkaline phosphatase(ALP), albumin, total bilirubin, direct bilirubin, gamma-GTP, BUN, creatinine(Cr), electrolyte
Change in postoperative recovery	after operation, and on the 1st, 2nd, 3rd, 5th, 7th and 15th postoperative days.	Complete blood count(CBC), prothrombin time(PT), activated partial thromboplastin time(APTT), aspartate aminotransferase(AST), alanine aminotransferase(ALT), alkaline phosphatase(ALP), albumin, total bilirubin, direct bilirubin, gamma-GTP, BUN, creatinine(Cr), electrolyte

Trial Locations

Locations (1)

Severance Hospital; 🇰🇷 Seoul, Korea, Republic of