COPreDict: Development of COPD prognostic routine for optimal therapy prediction on the basis of lipid microbial biomarkers and AI-based modelling

Recruiting

Conditions: J44
Other chronic obstructive pulmonary disease

Registration Number: DRKS00031530

Lead Sponsor: niversitätsklinikum Frankfurt

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 50

Inclusion Criteria

Physician-diagnosed COPD
- Hospitalisation with a primary diagnosis of an acute exacerbation of COPD, max. 72h prior to inclusion
or:
- Hospitalisation due to primary diagnosis of pneumonia with concurrent diagnosis of an acute exacerbation of COPD , max. 72h prior to inclusion
- Min. 10 Pack years
- Written informed consent

Exclusion Criteria

- Life expectancy < 6 months
- Patients with a palliative treatment goal
- High likelihood of lethal outcome within 72h

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in Clinical COPD Questionnaire (CCQ) scores 31.12.2024

Secondary Outcome Measures

Name	Time	Method
- Length of hospitalisation<br>- Complications during hospitalisation (e.g. admission to intensive care, need for increased respiratory support)<br>- Differences in clinical and laboratory parameters between patients responding to treatment vs. those who do not<br>- Readmission rates within 30 days<br>- Newly required or increased need for longterm supplemental oxygen<br>- Change in spirometry results pre / post exacerbation (90 ± 7 days after hospital admission)<br>- Changes in CAT scores and mMRC scores between the visit dates<br>- Change in maintenance therapy