Usefulness of Neutrophil Gelatinase-associated Lipocalin(NGAL) to Confirm Acute Kidney Function Decrease of the Patients Who Had Non-cardiac Surgery

Completed

• Conditions: Chronic Kidney Disease
• Interventions: Other: The level of NGAL after pre op,post op 4hr, post op 12hr

• Registration Number: NCT02233010
• Lead Sponsor: Inje University

Brief Summary

Although post-op renal function decrease is determined by serum creatinine, serum creatinine has disadvantages that it increases a long time after renal function decrease and it has various increasing time based on the level of renal function. Neutrophil Gelatinase-associated Lipocalin (NGAL's) usefulness as an evidence for acute kidney damage occurring from post-op cardiac surgery, being critical patients and contrast medium use is already proven.

But NGAL's usefulness for renal function after non-cardiac surgery is not proven and especially, NGAL's usefulness for renal injury after non-cardiac surgery in chronic renal disease patients is not proven.Therefore, the investigators will study about renal function decrease after non-cardiac surgery with NGAL and serum creatinine.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-02
• Primary Completion: 2014-08
• Status Verified: 2014-09
• Study First Submitted: 2014-09-01
• Study First Submitted QC: 2014-09-05
• Last Update Submitted: 2014-09-05
• Study First Posted: 2014-09-08
• Last Update Posted: 2014-09-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 43

Inclusion Criteria

• 43 patients who had non-cardiac surgery in Seoul Paik Hospital.

Exclusion Criteria

• have viral hepatitis and Aspartate aminotransferase, Alanine aminotransferase > 2 time of normal level
• severe lung disease
• severe heart failure ( Ejection Fraction < 40% )
• pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
kidney function decreased group	The level of NGAL after pre op,post op 4hr, post op 12hr	kidney function decreased group : defined by the increased level of NGAL after post operation 4hrs
kidney function normal group	The level of NGAL after pre op,post op 4hr, post op 12hr	kidney function normal group : defined by the normal level of NGAL after post operation 4hrs

Primary Outcome Measures

Name	Time	Method
serum NGAL level	up to post operation 12 hours