Improving Magnetic Seizure Therapy in Major Depressive Disorder

Not Applicable

• Conditions: Mental Health - Depression; Treatment Resistant Major Depression

• Registration Number: ACTRN12616000406404
• Lead Sponsor: Professor Paul Fitzgerald

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-03-30
• Last Update Posted: 16 November 2020

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Age 18-75 and a DSM-IV diagnosis of a major depressive episode (uni or bipolar depression) (diagnosis made using the standard structured clinical interview for the DSM-IV (SCID I) instrument). Patients with psychotic symptoms as part of their mood episode will not be excluded if able to give informed consent.

?Montgomery Asberg depression rating scale (MADRS) score of > 20(moderate – severe depression).

Have treatment resistant depression at Stage II of the Thase and Rush classification. This requires failure to respond to adequate courses of several courses of antidepressants.

Demonstrated capacity to give informed consent

Exclusion Criteria

Patients who are too unwell to undergo general anesthetic.

Patients with metallic implants in the head, cardiac pacemakers, cochlear implants or other implanted electronic devices

Treatment with ECT in the last two months

Presence of another DSM-IV Axis I psychiatric disorder (on MINI) other than bipolar disorder

Presence of substance abuse or dependence during the last six months

Current pregnancy

Past history of stroke, neurodegenerative disorder or other major neurological illness

Study & Design

• Study Type: Interventional
• Study Design: Not specified