Epidemiology of Sepsis in China

Completed

• Conditions: Sepsis

• Registration Number: NCT02448472
• Lead Sponsor: Jianfeng Xie

Brief Summary

Sepsis is a common cause for morbidity and mortality in critically ill patients. In USA, the incidence of sepsis is about 3/1000 population. However, the incidence of sepsis varies among different clinic trails. In addition, clinician empirical select antibiotic according to the epidemiology of sepsis, however, the etiology of sepsis is various in different studies. In China, the MDRO is much higher than western country. There is no study about the epidemiology of sepsis in China. Therefore, it is necessary to conduct a study about it in China.

Detailed Description

Sepsis,especially severe sepsis is a major cause of admission to the intensive care unit (ICU) and death. In USA, the incidence of sepsis is about 3/1000 population. However, the incidence of sepsis varies among different clinic trails. Between 6 and 54% of patients admitted to ICUs have severe sepsis and the mortality rate for these patients varies from 20 to 60%. There is no exactly results of incidence of sepsis in China.

In addition, clinician empirical select antibiotic according to the epidemiology of sepsis, however, the etiology of sepsis is various in different studies. In EPIC II study, the organisms of sepsis include Gram-positive microorganisms (69.8%),Gram-negative microorganisms(62.2%) and fungi (17%). In China, the MDRO is much higher than western country. In contrast to EPIC II study, one study in China showed that the organisms of sepsis include Gram-positive microorganisms (14.5%),Gram-negative microorganisms(62.5%) and fungi (2.2%). Therefore, it is necessary to conduct a study about epidemiology of sepsis in China.

Study Timeline

• Study First Submitted: 2015-04-11
• Study First Submitted QC: 2015-05-14
• Study First Posted: 2015-05-19
• Status Verified: 2015-10
• Study Start: 2015-11
• Primary Completion: 2015-12
• Study Completion: 2016-01
• Last Update Submitted: 2016-02-14
• Last Update Posted: 2016-02-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 2000

Inclusion Criteria

sepsis patients who admitted into ICU during research period (include patients with sepsis at ICU admission and patients who has new sepsis during ICU period)

Exclusion Criteria

The patients with second sepsis in ICU

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mortality	Sepsis and severe sepsis patients will be assessed up to 90 days
Incidence	Patients will be assessed up to 90 days

Secondary Outcome Measures

Name	Time	Method
etiology	The pathogen of sepsis will be assessed up to 90 days

Trial Locations

Locations (1)

Zhongda hospital, Southeast University; 🇨🇳 Nanjing, Jiangsu, China