NCT00993902已完成4 期
Double and Single Intrauterine Insemination In Controlled Ovarian Stimulation (COH) Cycles With Multifollicular Development
适应症
干预措施
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 228
- 试验地点
- 1
- 主要终点
- ongoing pregnancy rates
研究概览
简要总结
Our hypothesis is double insemination will improve pregnancy rates in coh cycles with more than one dominant follicles (>16mm).
详细描述
Metaanalysis for the effects of double IUI demonstrates that effects of this procedure is not different from single IUI. It is known that nearly 25% of coh cycles is evident by monofollicular development.For this reason it is possible that this monofollicular cycles in the studies could decrease the effects of double IUI.
Inclusion criteria:
- Patients with unexplained infertility or mild male factor infertility whom admitted to the COH+IUI programme in our infertility unit.
- Female age <37 years old.
- Baseline FSH <12 mIU/L
- Total antral follicle count>6
- During the first three cycles of COH+IUI
- Minimum 2 follicles >16 mm at the day of HCG.
Primary outcome:
Ongoing pregnancy rates
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 37 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Unexplained and mild male factor infertile patients
- •Minimum 2 follicles >16 mm at the day of HCG
- •First 3 cycles
排除标准
- •Basal FSH >12 mIU/L
- •Total antral follicle count<6
- •Severe male factor infertility
研究组 & 干预措施
Single IUI
Sham Comparator
Single IUI will be carried on after 36-38 hours of HCG administration
干预措施: Intrauterine insemination (single) (Procedure)
Double IUI
Active Comparator
干预措施: Double intrauterine insemination (Procedure)
结局指标
主要结局
ongoing pregnancy rates
时间窗: pregnancy >12 weeks of gestation
次要结局
- The effects of different coh regimens on outcomes(14 days after IUI procedure)
研究者
研究点 (1)
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