Mnemonic Strategy Versus Spaced Retrieval Training in Those With Mild Cognitive Impairment

Not Applicable

Completed

• Conditions: Mild Cognitive Impairment
• Interventions: Behavioral: spaced retrieval training; Behavioral: mnemonic strategy training

• Registration Number: NCT04533204
• Lead Sponsor: VA Office of Research and Development

Brief Summary

This study compared two active cognitive interventions to evaluate whether one improved memory more than the other in patients with mild cognitive impairment. Participants were randomized to either memory strategy training or spaced retrieval training and completed memory tests before and after 3 training sessions. Participants returned 1 month after treatment to see how well they remembered the learned information. Brain scans (functional MRI) were collected before and after the interventions to see if training changed the way brain regions were functioning.

Detailed Description

Individuals with MCI were randomized to 3 sessions of mnemonic strategy or spaced retrieval training that focused on object location associations. Across these training sessions, each group received 9 training trials for each of the 45 trained stimuli. Task-fMRI was acquired before and after training. Memory was again evaluated 1 month after the last training session. The primary outcome measure was memory for the "trained" stimuli while secondary outcome was accuracy for novel stimuli acquired outside of the MRI environment.

Study Timeline

• Study Start: 2010-08-01
• Primary Completion: 2014-06-30
• Study Completion: 2014-07-30
• Study First Submitted: 2020-08-25
• Study First Submitted QC: 2020-08-25
• Study First Posted: 2020-08-31
• Status Verified: 2020-11
• Results First Submitted: 2020-11-18
• Results First Submitted QC: 2021-02-26
• Last Update Submitted: 2021-02-26
• Results First Posted: 2021-03-23
• Last Update Posted: 2021-03-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 59

Inclusion Criteria

-Diagnosis of MCI according to Petersen (2004) criteria, right handed

Exclusion Criteria

• Diagnosis of other neurological condition,
• active drug/alcohol abuse/dependence,
• moderate-severe depression or other Axis I diagnoses.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Spaced retrieval training	spaced retrieval training	Training using spaced retrieval
Mnemonic strategy training	mnemonic strategy training	Training using mnemonic strategies

Primary Outcome Measures

Name	Time	Method
Percent of Correct Object Location Associations Assessed up to 1 Month Post-treatment	up to 1 month after last training session	Change in memory for 45 trained object location associations

Secondary Outcome Measures

Name	Time	Method
Change in Accuracy (vs. Baseline) on Novel Object Location Associations	up to 1 month after last training session	Change in accuracy for novel object location associations using a touchscreen task; distance measured in cm from actual location

Trial Locations

Locations (1)

VA Ann Arbor Healthcare System, Ann Arbor, MI; 🇺🇸 Ann Arbor, Michigan, United States