ISRCTN40310490
Completed
未知
A pilot cluster randomised clinical trial of the use of selective gut decontamination in critically ill children: Paediatric Intensive Care and Infection Control (PICnIC)
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
- Enrollment
- 361
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
2022 Protocol article in https://pubmed.ncbi.nlm.nih.gov/35277414/ (added 14/03/2022) 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/38066012/ (added 11/12/2023) 2024 Results article in https://pubmed.ncbi.nlm.nih.gov/38421007/ (added 01/03/2024)
Investigators
Eligibility Criteria
Inclusion Criteria
- •Pilot cRCT:
- •1\. Aged \>37 weeks (corrected gestational age) and \<16 years
- •2\. Receiving mechanical ventilation expected to last at least 48 h (and expected to remain so until the day after tomorrow)
- •Mixed methods study:
- •3\. Online survey/telephone interviews: All health care professionals working in a PICU within the UK
- •4\. Focus Groups: All healthcare professionals working in the two PICUs selected for focus groups
- •5\. Survey/telephone interviews: Parents/legal representatives of all recruited patients
Exclusion Criteria
- •1\. Known allergy, sensitivity or interaction to polymyxin E, tobramycin, or nystatin
- •2\. Known to be pregnant
- •3\. Death perceived as imminent
Outcomes
Primary Outcomes
Not specified
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