A pilot cluster randomised clinical trial of the use of selective gut decontamination in critically ill children: Paediatric Intensive Care and Infection Control (PICnIC)

Cambridge University Hospitals NHS Foundation Trust0 个研究点目标入组 361 人开始时间: 2020年10月30日最近更新: 2024年3月11日

试验速览

2022 Protocol article in https://pubmed.ncbi.nlm.nih.gov/35277414/ (added 14/03/2022) 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/38066012/ (added 11/12/2023) 2024 Results article in https://pubmed.ncbi.nlm.nih.gov/38421007/ (added 01/03/2024)

•Pilot cRCT:
•1. Aged >37 weeks (corrected gestational age) and <16 years
•2. Receiving mechanical ventilation expected to last at least 48 h (and expected to remain so until the day after tomorrow)
•Mixed methods study:
•3. Online survey/telephone interviews: All health care professionals working in a PICU within the UK
•4. Focus Groups: All healthcare professionals working in the two PICUs selected for focus groups
•5. Survey/telephone interviews: Parents/legal representatives of all recruited patients

•1. Known allergy, sensitivity or interaction to polymyxin E, tobramycin, or nystatin
•2. Known to be pregnant
•3. Death perceived as imminent

发起方