NCT01424735已完成不适用
Outcomes of TLR-9 Antagonism in Steroid Resistant Optic Neuritis; A Pilot Study
Sudhalkar Eye Hospital1 个研究点 分布在 1 个国家目标入组 8 人开始时间: 2006年7月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 8
- 试验地点
- 1
- 主要终点
- Improvement in all aspects of visual function
研究概览
简要总结
Although idiopathic steroid resistant optic neuritis is very uncommon, there is no established treatment protocol for such patients. Toll like receptors (TLRs) especially TLR-9 has been shown to play a role in the pathogenesis of optic neuritis. This small case series aims to determine whether immunomodulators directed specifically at TLR-9(i.e. TLR-9 antagonism)play any role in improving the visual function in such patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Unilateral Steroid Resistant Optic Neuritis
排除标准
- •bilateral optic neuritis
- •Associated Systemic disease
- •Prior treatment received
研究组 & 干预措施
Mw.
Experimental
Administration of immunomodulator Mw.
干预措施: Mycobacterium w.(Mw)-freeze dried extract 0.5ml (Drug)
结局指标
主要结局
Improvement in all aspects of visual function
时间窗: upto 6 months
次要结局
未报告次要终点
研究者
Aditya Sudhalkar
Dr. Aditya Sudhalkar
Sudhalkar Eye Hospital
研究点 (1)
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